Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 107595..108097 Replicon chromosome
Accession NZ_CP068802
Organism Escherichia coli strain RIVM_C018249

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JNN40_RS00510 Protein ID WP_000767829.1
Coordinates 107843..108097 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A377LDC7
Locus tag JNN40_RS00505 Protein ID WP_001259257.1
Coordinates 107595..107846 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN40_RS00480 102869..103339 - 471 WP_201491126.1 hypothetical protein -
JNN40_RS00485 103417..104322 - 906 WP_157943132.1 Mu-like prophage major head subunit gpT family protein -
JNN40_RS00490 104883..106211 - 1329 WP_202859892.1 histidinol dehydrogenase -
JNN40_RS00495 106217..107116 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
JNN40_RS00500 107262..107312 - 51 WP_001364200.1 his operon leader peptide -
JNN40_RS00505 107595..107846 + 252 WP_001259257.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JNN40_RS00510 107843..108097 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JNN40_RS00515 108180..109004 + 825 WP_000754737.1 SDR family oxidoreductase -
JNN40_RS00520 109050..109979 + 930 WP_000803351.1 LysR family transcriptional regulator -
JNN40_RS00525 110194..110256 + 63 WP_010723108.1 membrane protein YoeI -
JNN40_RS00530 110246..111604 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T187890 WP_000767829.1 NZ_CP068802:107843-108097 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T187890 NZ_CP090095:c1402308-1402006 [Neorhizobium galegae]
ATGATCGAAATCCAGGAAACCGAAATCTATTCGACTTGGTTTGCCAGGTTGCGGGACGAGCGGGCCAAAGCCCGGATCAA
TGCCCGCATCTATCGTTTGTCGCTCGGCAATCCCGGCGATGTAAAGCCTGTCGGTTCCGGTGTCAGCGAAATGCGGGTCG
ATTACGGACCGGGTTTTCGGATCTATTTCATCCGCCGTGGCCAGGCATTCGTCGTCCTGCTCTGCGGCGGAGACAAATCT
AGCCAGACGGAAGATATCGTATCGGCCAAAAAGCTGGCGGCTGGTCTGGAGGGCCGGAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9306.64 Da        Isoelectric Point: 5.8289

>AT187890 WP_001259257.1 NZ_CP068802:107595-107846 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIK

Download         Length: 252 bp

>AT187890 NZ_CP090095:c1402009-1401710 [Neorhizobium galegae]
ATGACGGTTGAGACAAAGAAATGGGATATCACCGAGCATCTGGACACCGATGAGCGTATCGCGCTCTTTCTGGAAGCGGT
GTTTGAAGATGGCGATCCGGCCGTGATCGCCGCGGCGATCGGCGATGTCGCCCGAGCCCGAGGCATGAGCCAGATCGCCA
AGGATGCCGGCCTCTCACGTGAAAATCTCTATCGAGCATTGAGTGAGGGCGGCAATCCCGAGTTCGCGACCATCCTGAAG
GTCATCCGAGCCATCGGCTACGATCTCACCATTGTACCGCATGGCTCCGCAGCTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A377LDC7

References