187865

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2043052..2043554 Replicon chromosome
Accession NZ_CP068801
Organism Escherichia coli strain RIVM_C018220

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JNN52_RS09850 Protein ID WP_000767829.1
Coordinates 2043300..2043554 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag JNN52_RS09845 Protein ID WP_001259255.1
Coordinates 2043052..2043303 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN52_RS09820 2038230..2039297 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JNN52_RS09825 2039297..2040367 - 1071 WP_000108943.1 histidinol-phosphate transaminase -
JNN52_RS09830 2040364..2041668 - 1305 WP_039267630.1 histidinol dehydrogenase -
JNN52_RS09835 2041674..2042573 - 900 WP_000131789.1 ATP phosphoribosyltransferase -
JNN52_RS09840 2042719..2042769 - 51 WP_071593552.1 his operon leader peptide -
JNN52_RS09845 2043052..2043303 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JNN52_RS09850 2043300..2043554 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JNN52_RS09855 2043637..2044461 + 825 WP_000754737.1 SDR family oxidoreductase -
JNN52_RS09860 2044507..2045436 + 930 WP_000803351.1 LysR family transcriptional regulator -
JNN52_RS09865 2045651..2045713 + 63 WP_010723108.1 membrane protein YoeI -
JNN52_RS09870 2045703..2047061 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
JNN52_RS09875 2047240..2048298 + 1059 WP_023568741.1 transport protein YeeE -
JNN52_RS09880 2048312..2048539 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T187865 WP_000767829.1 NZ_CP068801:2043300-2043554 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T187865 NZ_CP090068:c47475-47188 [Acinetobacter sp. SH20PTE14]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATGTCTCTTTCGAAACTGCGAG
CCTTGTTTTTGAAGATCCACTACGGATCTCAATCCAGGACAGACATACCGATGGCGAAGAACGTTGGCAGACCATTGGAA
AAGTAAAAGGCGTACTAATGCTCTTAGTAGCTCATACCATCTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGACAGGTAACTAAAGCGGAGCGAGATAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT187865 WP_001259255.1 NZ_CP068801:2043052-2043303 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT187865 NZ_CP090068:c47201-46887 [Acinetobacter sp. SH20PTE14]
ATGAGCATGGTTAGATACTCACGCAAAGAGCTGAATGAAAAATTCAGCGACAAGCAAGATGCTGAAATTGAACGCTTGCT
TGCTAAAGGTATAGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATGACTGATTGGAGTAATGCTGCACGCC
ATAATCAATTCTATCGCCCTGTGAAGCAACAAACTTCTATTCGGTTAGATGCTGATGTGCTTGCTTGGTTCAAAGCACAA
GGTAAAGGTTATCAAACACGAATGAATGAAATTTTACGGGATGCTATGCTTAAAGAATTAAAAAATCATCAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References