Detailed information of TA system TA187819

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4279261..4279519
• Replicon: chromosome
• Accession: NZ_CP068799
• Organism: Escherichia coli strain RIVM_C017887

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JNN46_RS20500
• Protein ID: WP_000809168.1
• Coordinates: 4279367..4279519 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4279261..4279318 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JNN46_RS20485	4275090..4276349	-	1260	WP_000494927.1	hypothetical protein	-
JNN46_RS20490	4276478..4277971	-	1494	WP_001314416.1	sulfatase-like hydrolase/transferase	-
JNN46_RS20495	4277991..4278752	-	762	WP_001274828.1	hypothetical protein	-
-	4279261..4279318	-	58	-	-	Antitoxin
JNN46_RS20500	4279367..4279519	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
JNN46_RS20505	4279624..4280754	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
JNN46_RS20510	4280843..4282759	-	1917	WP_000516135.1	molecular chaperone DnaK	-
JNN46_RS20515	4283131..4283535	+	405	WP_000843689.1	DUF2541 family protein	-
JNN46_RS20520	4283561..4284274	+	714	WP_001102393.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T187819 WP_000809168.1 NZ_CP068799:4279367-4279519 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T187819 NZ_CP090028:c3213640-3213338 [Serratia ureilytica]
ATTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGATGTCCT
CTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGGAGATTG
AGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCCGTTGGT
AATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT187819 NZ_CP068799:c4279318-4279261 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin