Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 737477..738170 Replicon chromosome
Accession NZ_CP068796
Organism Escherichia coli strain RIVM_C012087

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag JNN38_RS03505 Protein ID WP_000415583.1
Coordinates 737477..737773 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JNN38_RS03510 Protein ID WP_000650107.1
Coordinates 737775..738170 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JNN38_RS03470 732565..732879 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
JNN38_RS03475 732910..733491 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JNN38_RS03480 733810..734142 + 333 WP_000917684.1 DUF2645 family protein -
JNN38_RS03485 734188..735537 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
JNN38_RS03490 735534..736193 - 660 WP_106106579.1 two-component system response regulator QseB -
JNN38_RS03495 736345..736737 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JNN38_RS03500 736790..737272 + 483 WP_106106578.1 GyrI-like domain-containing protein -
JNN38_RS03505 737477..737773 + 297 WP_000415583.1 type II toxin-antitoxin system toxin MqsR Toxin
JNN38_RS03510 737775..738170 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JNN38_RS03515 738303..739910 + 1608 WP_106106577.1 ABC transporter substrate-binding protein -
JNN38_RS03520 740048..742306 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / papX 725589..897916 172327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11216.99 Da        Isoelectric Point: 8.9070

>T187734 WP_000415583.1 NZ_CP068796:737477-737773 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGLV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T187734 NZ_CP089979:5045289-5045531 [Fulvivirga sp. W9P-11]
ATGTCTAAGAAACAAAAACTTATAGATAGATTTCTAGGCATGCCATCTGATTTTCATTATGATGAGATGGTTCAGCTACT
AAGCTATTTCGGATATAGCGAGGTTAAGAAAGGAAAAACCTCAGGATCTCGAGTTAAGTTTAGAAATGATGCTGGCATCA
ACATATTACTTCATAAACCACACCCAAGTGGAATCATGAAAAAATATCAGATGAAACAAATAAAGGAAACATTAGGAATA
TGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT187734 WP_000650107.1 NZ_CP068796:737775-738170 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT187734 NZ_CP089979:5045528-5045866 [Fulvivirga sp. W9P-11]
ATGAAATACCTGAAATATAAAGGCTACACAGGAAGTATTGAATATAGCCCTGAAGACAATTTAATGTATGGAAAAGTACT
AGGAATAAAAGGTCTCATATCTTATGAGGGTCAAACTGGGAAGCAGCTCGAAGAAGATTTTAAAGAGGCTGTAGATACTT
ATCTTGAGGATTGCAAAGAGGAAAATTCAAAGCCTGAGAAACCCTTTAAAGGAAGTTTTAATGTGCGGATTCCTTCAAGC
CTCCATCAGCAGGCAGCTCTTTTGGCTATGGAAACCCAAACTTCGCTGAACAGTTTAGTCACAGAAGCCATCCGATTTCG
TATTTCAAAAGAGGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References