Detailed information of TA system TA187669

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 9817..10380
• Replicon: plasmid p14AME19-2
• Accession: NZ_CP068714
• Organism: Staphylococcus pseudoxylosus strain 14AME19

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JMB28_RS13945
• Protein ID: WP_099265888.1
• Coordinates: 9817..10131 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JMB28_RS13950
• Protein ID: WP_202847954.1
• Coordinates: 10132..10380 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JMB28_RS13910	4913..6202	+	1290	WP_099265891.1	arsenite efflux transporter membrane subunit ArsB	-
JMB28_RS13915	6220..6615	+	396	WP_029379010.1	arsenate reductase (thioredoxin)	-
JMB28_RS13920	6780..6920	-	141	Protein_10	rhodanese-like domain-containing protein	-
JMB28_RS13925	7118..7576	+	459	WP_107549703.1	MarR family transcriptional regulator	-
JMB28_RS13930	7563..8906	+	1344	WP_029379008.1	NAD(P)/FAD-dependent oxidoreductase	-
JMB28_RS13935	8981..9269	+	289	Protein_13	hypothetical protein	-
JMB28_RS13940	9698..9793	-	96	WP_014287283.1	type I toxin-antitoxin system Fst family toxin	-
JMB28_RS13945	9817..10131	-	315	WP_099265888.1	Txe/YoeB family addiction module toxin	Toxin
JMB28_RS13950	10132..10380	-	249	WP_202847954.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JMB28_RS13955	10681..11484	-	804	WP_202847955.1	helix-turn-helix domain-containing protein	-
JMB28_RS13960	11561..12202	-	642	WP_202847956.1	helix-turn-helix transcriptional regulator	-
JMB28_RS13965	12404..12838	-	435	WP_202847947.1	hypothetical protein	-
JMB28_RS13970	13540..13746	+	207	WP_099265884.1	DUF3923 family protein	-
JMB28_RS13975	14014..14361	-	348	WP_037538777.1	metalloregulator ArsR/SmtB family transcription factor	-
JMB28_RS13980	14379..15008	-	630	WP_202847948.1	CadD family cadmium resistance transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..23177	23177

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11957.77 Da
• Isoelectric Point: 9.5601

>T187669 WP_099265888.1 NZ_CP068714:c10131-9817 [Staphylococcus pseudoxylosus]
VAKLNVTFSPQAFDDYEYFQIKDRKKVKRMNQLLKSISRDGTLDAIGKPEKLVGNFFGYYSRRINQEHRLVYTVNDIILL
IGSAYAYIFTDGIIMESPISQASI

Nucleotide

• Length: 315 bp

>T187669 NZ_CP089940:c3877188-3876787 [Erwinia tracheiphila]
GTGGCCCTGTGGCACTCTGAGCTGCGGGTCTCATGGCGAGCACAGTGGTTTTCATTGCTGCTGCACGGCGTGGCGATCCT
GATTGTGCTGCTGGCACCCTGGCCGGCCAGCTATACGGTGGTGTGGATGTCACTCCTCACGCTAACGATATTTGAGTGCG
TGCGGAGCCAGCGGAGAATAGGCAACCGTGAGGGAGAAATTGCCCTGTTTGAGGGGCGGCAGGTGCAATGGCGGCAGAAG
CGCTGGCAGATTCGCGGGCGACCCTGGATTACCCGACAGGCTATTTTAATGACGCTGCGTTCAGCAACCGGAGAACGCGA
AAAGCTTTGGTTATTTTCAGACAGTATGTCCGCGGAAGACTGGCGATCGCTTCGAAAGCAATTACTTCGGGCGGCTCTAT
AG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9511.82 Da
• Isoelectric Point: 8.4203

>AT187669 WP_202847954.1 NZ_CP068714:c10380-10132 [Staphylococcus pseudoxylosus]
MIVKSYSYVRKNFKDMINKVNNDSDTITITTKDRNAVIMSEDNYNEIMETLYLQQNPANSKHLSESIENLKRGNVKAKDI
LI

Nucleotide

• Length: 249 bp

>AT187669 NZ_CP089940:c3877435-3877169 [Erwinia tracheiphila]
ATGGATATAAGTAATAAAGCCCGTGTTCACTGGGCCTGCCGTCGTGGCATGCGTGAACTGGATATCTCTATTATGCCGTT
TTTTGAATATGAGTACGATTCACTGAGCGACAGTGACAAACTGGTTTTTGTACGCCTGTTGGAAAATGACGATCCCGATC
TTTTTAACTGGCTGATGAATTACGGCGAGCCGCCAGACACCGAGCTGAAACGTATGGTGCTTCTCATTCAGCAGCGAAAC
AAGCAACGTGGCCCTGTGGCACTCTGA