Detailed information of TA system TA187597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 273885..274487
• Replicon: chromosome
• Accession: NZ_CP068696
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain NCCP16345

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: JKV46_RS01435
• Protein ID: WP_001159630.1
• Coordinates: 274176..274487 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JKV46_RS01430
• Protein ID: WP_000362050.1
• Coordinates: 273885..274175 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKV46_RS01415 (271378)	271378..272280	+	903	WP_000331361.1	formate dehydrogenase subunit beta	-
JKV46_RS01420 (272277)	272277..272912	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
JKV46_RS01425 (272909)	272909..273838	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
JKV46_RS01430 (273885)	273885..274175	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
JKV46_RS01435 (274176)	274176..274487	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
JKV46_RS01440 (274705)	274705..275634	+	930	WP_001127703.1	alpha/beta hydrolase	-
JKV46_RS01445 (275720)	275720..276031	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
JKV46_RS01450 (276028)	276028..276474	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
JKV46_RS01455 (276489)	276489..277430	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
JKV46_RS01460 (277475)	277475..277912	-	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
JKV46_RS01465 (277909)	277909..278781	-	873	WP_000921427.1	virulence factor BrkB family protein	-
JKV46_RS01470 (278775)	278775..279374	-	600	WP_000965695.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T187597 WP_001159630.1 NZ_CP068696:c274487-274176 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T187597 NZ_CP089927:c1323758-1323441 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT187597 WP_000362050.1 NZ_CP068696:c274175-273885 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT187597 NZ_CP089927:c1323970-1323755 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64