Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
Location | 780715..781490 | Replicon | chromosome |
Accession | NZ_CP068689 | ||
Organism | Klebsiella pneumoniae subsp. pneumoniae strain RJBSI76 |
Toxin (Protein)
Gene name | TacT2 | Uniprot ID | A0A1Q4Q548 |
Locus tag | I5002_RS03900 | Protein ID | WP_004150910.1 |
Coordinates | 781005..781490 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | TacA2 | Uniprot ID | W8UEW1 |
Locus tag | I5002_RS03895 | Protein ID | WP_004150912.1 |
Coordinates | 780715..781008 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I5002_RS03875 | 775923..776525 | - | 603 | WP_062954968.1 | short chain dehydrogenase | - |
I5002_RS03880 | 776623..777534 | + | 912 | WP_004188550.1 | LysR family transcriptional regulator | - |
I5002_RS03885 | 777535..778683 | - | 1149 | WP_004150915.1 | PLP-dependent aspartate aminotransferase family protein | - |
I5002_RS03890 | 778694..780070 | - | 1377 | WP_004217775.1 | cystathionine beta-synthase | - |
I5002_RS03895 | 780715..781008 | + | 294 | WP_004150912.1 | DUF1778 domain-containing protein | Antitoxin |
I5002_RS03900 | 781005..781490 | + | 486 | WP_004150910.1 | GNAT family N-acetyltransferase | Toxin |
I5002_RS03905 | 782194..782787 | + | 594 | WP_004188553.1 | hypothetical protein | - |
I5002_RS03910 | 782884..783100 | + | 217 | Protein_769 | transposase | - |
I5002_RS03915 | 783706..784578 | + | 873 | WP_004188557.1 | ParA family protein | - |
I5002_RS03920 | 784578..784961 | + | 384 | WP_004150906.1 | hypothetical protein | - |
I5002_RS03925 | 784954..786321 | + | 1368 | WP_004150905.1 | replicative DNA helicase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 782884..783036 | 152 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17551.59 Da Isoelectric Point: 8.8818
>T187566 WP_004150910.1 NZ_CP068689:781005-781490 [Klebsiella pneumoniae subsp. pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A
Download Length: 486 bp
>T187566 NZ_CP089924:c294221-293739 [Lysobacter sp. 5GHs7-4]
ATGCACACCCCGCGCTGGTCGTTCCAGCCGCTCAGCGGCGCCGGCGCGGCGATCTCCGGCGGCCGCCTCAATCGGCCCGG
CATCGACGCCCTGTACCTGGCGCTGGAACCGGAAACCGCGGTCGAGGAGTTCCGCCAGGACGATCCGCTGGTGCGCCCCG
GCACCCTGGTCGCCTACCGCGCCACCATCGCGCGCGTGGCCGACTTCCGCGCCGGCTACGACCCCGCGCACTGGCCGCCG
CTGTGGCAGGAACTGTCCTGCAACTGGAAGCGCATGGCGTTCCTGGACGAGATCGAGCCGCCCAGCTGGGTGATCGCCGA
CGACGCGCGCGCCGCCGGCCTGGCCGCGATCGCGTTCCCGTCCACGCGCCGCGCCGGCGGTTCCAACCTGGTGGTCTATC
CCGACCTGCTGGGCGCCGACGACCGCCTGCTGGTGCACGACCCGCGCATGGACCTGCCGATCGATCCGTCCAGCTGGCGC
TGA
ATGCACACCCCGCGCTGGTCGTTCCAGCCGCTCAGCGGCGCCGGCGCGGCGATCTCCGGCGGCCGCCTCAATCGGCCCGG
CATCGACGCCCTGTACCTGGCGCTGGAACCGGAAACCGCGGTCGAGGAGTTCCGCCAGGACGATCCGCTGGTGCGCCCCG
GCACCCTGGTCGCCTACCGCGCCACCATCGCGCGCGTGGCCGACTTCCGCGCCGGCTACGACCCCGCGCACTGGCCGCCG
CTGTGGCAGGAACTGTCCTGCAACTGGAAGCGCATGGCGTTCCTGGACGAGATCGAGCCGCCCAGCTGGGTGATCGCCGA
CGACGCGCGCGCCGCCGGCCTGGCCGCGATCGCGTTCCCGTCCACGCGCCGCGCCGGCGGTTCCAACCTGGTGGTCTATC
CCGACCTGCTGGGCGCCGACGACCGCCTGCTGGTGCACGACCCGCGCATGGACCTGCCGATCGATCCGTCCAGCTGGCGC
TGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10901.46 Da Isoelectric Point: 6.3783
>AT187566 WP_004150912.1 NZ_CP068689:780715-781008 [Klebsiella pneumoniae subsp. pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE
Download Length: 294 bp
>AT187566 NZ_CP089924:c294631-294260 [Lysobacter sp. 5GHs7-4]
GTGTCCGCCGCCGCCTTCGACACCTTCCTGGAAACCCTGCGCGAACCCTCGCGCCCGACGCTGTCGCCGGTGCGTATGGC
CCAGGCCCTGCACATGGGCGTGAGCGACCTGGCCGGCCTGGCGCGCGTGCACCGCAACACGGTCACCGGCAATCCGGAGT
CCTCGCAGCTGCAGGGCGCCTTGCGCGACATCGTCAAAGTGCTGGCCGCGGCCTACCGGGTCAACGACGACCGCGAGCGC
ACGCTGTTCTGGTTCATCAATCATCCGATCGCCGAGTTCGGTTACCAGACCGCCGCCGACCTGGTGCGCGACGGCAAATC
CGAGGCGGTGATCCGCTACCTGGCGACGTTGGAAGGCGGCGCCACCGGATGA
GTGTCCGCCGCCGCCTTCGACACCTTCCTGGAAACCCTGCGCGAACCCTCGCGCCCGACGCTGTCGCCGGTGCGTATGGC
CCAGGCCCTGCACATGGGCGTGAGCGACCTGGCCGGCCTGGCGCGCGTGCACCGCAACACGGTCACCGGCAATCCGGAGT
CCTCGCAGCTGCAGGGCGCCTTGCGCGACATCGTCAAAGTGCTGGCCGCGGCCTACCGGGTCAACGACGACCGCGAGCGC
ACGCTGTTCTGGTTCATCAATCATCCGATCGCCGAGTTCGGTTACCAGACCGCCGCCGACCTGGTGCGCGACGGCAAATC
CGAGGCGGTGATCCGCTACCTGGCGACGTTGGAAGGCGGCGCCACCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1Q4Q548 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GVL4 |