Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 750876..751393 | Replicon | chromosome |
| Accession | NZ_CP068682 | ||
| Organism | Staphylococcus aureus strain NCCP11854 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | JKV48_RS03475 | Protein ID | WP_000113263.1 |
| Coordinates | 751127..751393 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | JKV48_RS03470 | Protein ID | WP_000584499.1 |
| Coordinates | 750876..751127 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JKV48_RS03440 (JKV48_03420) | 746576..747295 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| JKV48_RS03445 (JKV48_03425) | 747292..748023 | + | 732 | WP_000615464.1 | amino acid ABC transporter ATP-binding protein | - |
| JKV48_RS03450 (JKV48_03430) | 748120..749370 | - | 1251 | WP_001012236.1 | FemA/FemB family glycyltransferase FmhA | - |
| JKV48_RS03455 (JKV48_03435) | 749625..749987 | + | 363 | WP_000819839.1 | DUF4467 domain-containing protein | - |
| JKV48_RS03460 (JKV48_03440) | 750006..750605 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| JKV48_RS03465 (JKV48_03445) | 750612..750703 | + | 92 | Protein_689 | hypothetical protein | - |
| JKV48_RS03470 (JKV48_03450) | 750876..751127 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| JKV48_RS03475 (JKV48_03455) | 751127..751393 | + | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| JKV48_RS03480 | 751428..751499 | + | 72 | WP_223200558.1 | hypothetical protein | - |
| JKV48_RS03485 (JKV48_03460) | 751687..753234 | + | 1548 | WP_000727757.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| JKV48_RS03490 (JKV48_03465) | 753420..753887 | + | 468 | WP_000153338.1 | SRPBCC domain-containing protein | - |
| JKV48_RS03495 (JKV48_03470) | 753974..754156 | + | 183 | WP_000079140.1 | hypothetical protein | - |
| JKV48_RS03500 (JKV48_03475) | 754360..755184 | + | 825 | WP_000594633.1 | formate/nitrite transporter family protein | - |
| JKV48_RS03505 (JKV48_03480) | 755597..756133 | + | 537 | WP_000185901.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T187516 WP_000113263.1 NZ_CP068682:751127-751393 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T187516 NZ_CP089880:353469-353816 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTCCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCGATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT187516 WP_000584499.1 NZ_CP068682:750876-751127 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT187516 NZ_CP089880:353816-354115 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGTGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGTGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|