Detailed information of TA system TA187514

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 725938..726122
• Replicon: chromosome
• Accession: NZ_CP068682
• Organism: Staphylococcus aureus strain NCCP11854

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: JKV48_RS03340
• Protein ID: WP_000482647.1
• Coordinates: 725938..726045 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	726062..726122 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JKV48_RS03315 (JKV48_03295)	721300..721773	+	474	WP_000456483.1	GyrI-like domain-containing protein	-
JKV48_RS03320 (JKV48_03300)	721896..723107	-	1212	WP_001191921.1	multidrug effflux MFS transporter	-
JKV48_RS03325 (JKV48_03305)	723290..723949	-	660	WP_000831298.1	membrane protein	-
JKV48_RS03330 (JKV48_03310)	724009..725151	-	1143	WP_001176863.1	glycerate kinase	-
JKV48_RS03335 (JKV48_03315)	725419..725805	+	387	WP_000779353.1	flippase GtxA	-
JKV48_RS03340 (JKV48_03320)	725938..726045	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	726062..726122	-	61	-	-	Antitoxin
JKV48_RS03345 (JKV48_03325)	726693..728405	+	1713	WP_001064821.1	ABC transporter ATP-binding protein	-
JKV48_RS03350 (JKV48_03330)	728481..730214	+	1734	WP_000488493.1	ABC transporter ATP-binding protein	-
JKV48_RS03355 (JKV48_03335)	730445..730612	+	168	WP_031845053.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T187514 WP_000482647.1 NZ_CP068682:725938-726045 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T187514 NZ_CP089879:c170091-169621 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATAGCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT187514 NZ_CP068682:c726122-726062 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin