Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1839953..1840646 Replicon chromosome
Accession NZ_CP068680
Organism Escherichia coli strain NCCP12480

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JKV47_RS08845 Protein ID WP_000415584.1
Coordinates 1839953..1840249 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JKV47_RS08850 Protein ID WP_000650107.1
Coordinates 1840251..1840646 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV47_RS08810 (1835041) 1835041..1835355 - 315 WP_000958598.1 putative quinol monooxygenase -
JKV47_RS08815 (1835386) 1835386..1835967 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JKV47_RS08820 (1836286) 1836286..1836618 + 333 WP_000917684.1 DUF2645 family protein -
JKV47_RS08825 (1836664) 1836664..1838013 - 1350 WP_000673409.1 quorum sensing histidine kinase QseC -
JKV47_RS08830 (1838010) 1838010..1838669 - 660 WP_115194746.1 quorum sensing response regulator transcription factor QseB -
JKV47_RS08835 (1838821) 1838821..1839213 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JKV47_RS08840 (1839266) 1839266..1839748 + 483 WP_000183505.1 GyrI-like domain-containing protein -
JKV47_RS08845 (1839953) 1839953..1840249 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JKV47_RS08850 (1840251) 1840251..1840646 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JKV47_RS08855 (1840779) 1840779..1842386 + 1608 Protein_1714 ABC transporter substrate-binding protein -
JKV47_RS08860 (1842524) 1842524..1844782 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T187494 WP_000415584.1 NZ_CP068680:1839953-1840249 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T187494 NZ_CP089874:3955298-3955516 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT187494 WP_000650107.1 NZ_CP068680:1840251-1840646 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT187494 NZ_CP089874:3954897-3955271 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References