Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3103334..3104015 Replicon chromosome
Accession NZ_CP068678
Organism Pseudomonas aeruginosa strain NCCP15783

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JKV45_RS14455 Protein ID WP_015503432.1
Coordinates 3103334..3103699 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JKV45_RS14460 Protein ID WP_016561576.1
Coordinates 3103692..3104015 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKV45_RS14425 (JKV45_14435) 3099339..3099773 - 435 WP_003158601.1 RidA family protein -
JKV45_RS14430 (JKV45_14440) 3099994..3100947 + 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
JKV45_RS14435 (JKV45_14445) 3100920..3101804 - 885 WP_019725847.1 LysR substrate-binding domain-containing protein -
JKV45_RS14440 (JKV45_14450) 3101905..3102330 + 426 WP_003163196.1 VOC family protein -
JKV45_RS14445 (JKV45_14455) 3102349..3102621 - 273 WP_003085667.1 hypothetical protein -
JKV45_RS14450 (JKV45_14460) 3102828..3103070 + 243 WP_043884955.1 hypothetical protein -
JKV45_RS14455 (JKV45_14465) 3103334..3103699 + 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JKV45_RS14460 (JKV45_14470) 3103692..3104015 + 324 WP_016561576.1 XRE family transcriptional regulator Antitoxin
JKV45_RS14465 (JKV45_14475) 3104131..3104250 - 120 Protein_2851 IS5/IS1182 family transposase -
JKV45_RS14470 (JKV45_14480) 3104245..3104637 + 393 Protein_2852 hypothetical protein -
JKV45_RS14475 3104637..3105640 + 1004 Protein_2853 tyrosine-type recombinase/integrase -
JKV45_RS14480 (JKV45_14495) 3105857..3106108 + 252 WP_124136459.1 hypothetical protein -
JKV45_RS14485 (JKV45_14500) 3106138..3107004 + 867 WP_023081971.1 hypothetical protein -
JKV45_RS14490 (JKV45_14505) 3107477..3108802 + 1326 WP_034030705.1 HipA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T187482 WP_015503432.1 NZ_CP068678:3103334-3103699 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

>T187482 NZ_CP089870:c4598732-4598199 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 5.8900

>AT187482 WP_016561576.1 NZ_CP068678:3103692-3104015 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQSRGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp

>AT187482 NZ_CP089870:c4599009-4598743 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References