Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 738417..739192 Replicon chromosome
Accession NZ_CP068618
Organism Klebsiella pneumoniae strain 41968

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag JMZ79_RS03690 Protein ID WP_004150910.1
Coordinates 738707..739192 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JMZ79_RS03685 Protein ID WP_004150912.1
Coordinates 738417..738710 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMZ79_RS03665 733625..734227 - 603 WP_002916735.1 short chain dehydrogenase -
JMZ79_RS03670 734325..735236 + 912 WP_004188550.1 LysR family transcriptional regulator -
JMZ79_RS03675 735237..736385 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
JMZ79_RS03680 736396..737772 - 1377 WP_004217775.1 cystathionine beta-synthase -
JMZ79_RS03685 738417..738710 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JMZ79_RS03690 738707..739192 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
JMZ79_RS03695 739896..740489 + 594 WP_004188553.1 hypothetical protein -
JMZ79_RS03700 740586..740802 + 217 Protein_727 transposase -
JMZ79_RS03705 741408..742280 + 873 WP_004188557.1 ParA family protein -
JMZ79_RS03710 742280..742663 + 384 WP_004150906.1 hypothetical protein -
JMZ79_RS03715 742656..744023 + 1368 WP_004150905.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 740586..740738 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T187430 WP_004150910.1 NZ_CP068618:738707-739192 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T187430 NZ_CP089797:3618874-3619131 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT187430 WP_004150912.1 NZ_CP068618:738417-738710 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT187430 NZ_CP089797:c3619049-3618717 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References