Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 9025..9564 Replicon plasmid p59493-45.9
Accession NZ_CP068607
Organism Klebsiella pneumoniae strain 59493

Toxin (Protein)


Gene name yafQ Uniprot ID J2DZM3
Locus tag JMZ77_RS26970 Protein ID WP_004150484.1
Coordinates 9025..9300 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A5H6MLU0
Locus tag JMZ77_RS26975 Protein ID WP_001570852.1
Coordinates 9304..9564 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMZ77_RS26915 4274..4468 - 195 WP_048242338.1 hypothetical protein -
JMZ77_RS26920 4485..5024 - 540 WP_032445848.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
JMZ77_RS26925 5040..5597 - 558 WP_053071116.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
JMZ77_RS26930 5600..5911 - 312 WP_096935507.1 hypothetical protein -
JMZ77_RS26935 6047..6340 - 294 WP_059446966.1 hypothetical protein -
JMZ77_RS26940 6337..6699 - 363 WP_119621188.1 hypothetical protein -
JMZ77_RS26945 6755..7123 - 369 WP_202808830.1 hypothetical protein -
JMZ77_RS26950 7120..7329 - 210 WP_159217127.1 hypothetical protein -
JMZ77_RS26955 7340..7867 - 528 WP_076050517.1 ankyrin repeat domain-containing protein -
JMZ77_RS26960 8200..8856 + 657 WP_059347887.1 hypothetical protein -
JMZ77_RS26965 8868..9074 - 207 WP_162184628.1 hypothetical protein -
JMZ77_RS26970 9025..9300 - 276 WP_004150484.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
JMZ77_RS26975 9304..9564 - 261 WP_001570852.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JMZ77_RS26980 9829..10086 - 258 WP_102016725.1 hypothetical protein -
JMZ77_RS26985 11295..11552 + 258 WP_102016725.1 hypothetical protein -
JMZ77_RS26990 11744..12328 - 585 WP_048242305.1 hypothetical protein -
JMZ77_RS26995 12340..12567 - 228 WP_001569532.1 hypothetical protein -
JMZ77_RS27000 12567..13043 - 477 WP_059347865.1 hypothetical protein -
JMZ77_RS27005 13157..13432 - 276 WP_060615702.1 hypothetical protein -
JMZ77_RS27010 13423..13728 - 306 WP_128334256.1 hypothetical protein -
JMZ77_RS27015 13774..14160 - 387 WP_048242309.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..45912 45912


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-83)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10750.40 Da        Isoelectric Point: 9.6586

>T187386 WP_004150484.1 NZ_CP068607:c9300-9025 [Klebsiella pneumoniae]
MTTRTIEYSGQFQKDVKKAQKRHKDMSKLKALMTLLINDALPLPQVYKDHPLQGNYKGYRDAHIEPDWLLIYKITDEVLR
FERTGTHSDLF

Download         Length: 276 bp

>T187386 NZ_CP089791:4607481-4607792 [Salmonella enterica subsp. enterica serovar Kentucky]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9239.63 Da        Isoelectric Point: 5.0336

>AT187386 WP_001570852.1 NZ_CP068607:c9564-9304 [Klebsiella pneumoniae]
MAANAFVRARIDETLKNEAAVVLAGMGLTVSDLVRITLTKVAKEKALPFDMRVPNELTANTIANSEKGVDVHTAKDADDL
FNQLGI

Download         Length: 261 bp

>AT187386 NZ_CP089791:4607789-4608235 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J2DZM3

Antitoxin

Source ID Structure
AlphaFold DB A0A5H6MLU0

References