Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-ohsC/Ldr(toxin)
Location 2181453..2181674 Replicon chromosome
Accession NZ_CP068591
Organism Escherichia coli strain EF7-18-58

Toxin (Protein)


Gene name ldrD Uniprot ID E0IV43
Locus tag JMY44_RS10270 Protein ID WP_000170926.1
Coordinates 2181453..2181560 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 2181613..2181674 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JMY44_RS10240 2176762..2177844 + 1083 WP_000804726.1 peptide chain release factor 1 -
JMY44_RS10245 2177844..2178677 + 834 WP_000456571.1 peptide chain release factor N(5)-glutamine methyltransferase -
JMY44_RS10250 2178674..2179066 + 393 WP_000200378.1 invasion regulator SirB2 -
JMY44_RS10255 2179070..2179879 + 810 WP_001257044.1 invasion regulator SirB1 -
JMY44_RS10260 2179915..2180769 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
JMY44_RS10265 2180918..2181025 - 108 WP_000170954.1 type I toxin-antitoxin system toxin Ldr family protein -
- 2181073..2181139 + 67 NuclAT_50 - -
- 2181073..2181139 + 67 NuclAT_50 - -
- 2181073..2181139 + 67 NuclAT_50 - -
- 2181073..2181139 + 67 NuclAT_50 - -
- 2181073..2181139 + 67 NuclAT_53 - -
- 2181073..2181139 + 67 NuclAT_53 - -
- 2181073..2181139 + 67 NuclAT_53 - -
- 2181073..2181139 + 67 NuclAT_53 - -
- 2181075..2181138 + 64 NuclAT_15 - -
- 2181075..2181138 + 64 NuclAT_15 - -
- 2181075..2181138 + 64 NuclAT_15 - -
- 2181075..2181138 + 64 NuclAT_15 - -
- 2181075..2181138 + 64 NuclAT_18 - -
- 2181075..2181138 + 64 NuclAT_18 - -
- 2181075..2181138 + 64 NuclAT_18 - -
- 2181075..2181138 + 64 NuclAT_18 - -
- 2181075..2181138 + 64 NuclAT_21 - -
- 2181075..2181138 + 64 NuclAT_21 - -
- 2181075..2181138 + 64 NuclAT_21 - -
- 2181075..2181138 + 64 NuclAT_21 - -
- 2181075..2181138 + 64 NuclAT_24 - -
- 2181075..2181138 + 64 NuclAT_24 - -
- 2181075..2181138 + 64 NuclAT_24 - -
- 2181075..2181138 + 64 NuclAT_24 - -
- 2181075..2181138 + 64 NuclAT_27 - -
- 2181075..2181138 + 64 NuclAT_27 - -
- 2181075..2181138 + 64 NuclAT_27 - -
- 2181075..2181138 + 64 NuclAT_27 - -
- 2181075..2181138 + 64 NuclAT_30 - -
- 2181075..2181138 + 64 NuclAT_30 - -
- 2181075..2181138 + 64 NuclAT_30 - -
- 2181075..2181138 + 64 NuclAT_30 - -
- 2181075..2181140 + 66 NuclAT_33 - -
- 2181075..2181140 + 66 NuclAT_33 - -
- 2181075..2181140 + 66 NuclAT_33 - -
- 2181075..2181140 + 66 NuclAT_33 - -
- 2181075..2181140 + 66 NuclAT_36 - -
- 2181075..2181140 + 66 NuclAT_36 - -
- 2181075..2181140 + 66 NuclAT_36 - -
- 2181075..2181140 + 66 NuclAT_36 - -
- 2181075..2181140 + 66 NuclAT_39 - -
- 2181075..2181140 + 66 NuclAT_39 - -
- 2181075..2181140 + 66 NuclAT_39 - -
- 2181075..2181140 + 66 NuclAT_39 - -
- 2181075..2181140 + 66 NuclAT_42 - -
- 2181075..2181140 + 66 NuclAT_42 - -
- 2181075..2181140 + 66 NuclAT_42 - -
- 2181075..2181140 + 66 NuclAT_42 - -
- 2181075..2181140 + 66 NuclAT_45 - -
- 2181075..2181140 + 66 NuclAT_45 - -
- 2181075..2181140 + 66 NuclAT_45 - -
- 2181075..2181140 + 66 NuclAT_45 - -
- 2181075..2181140 + 66 NuclAT_48 - -
- 2181075..2181140 + 66 NuclAT_48 - -
- 2181075..2181140 + 66 NuclAT_48 - -
- 2181075..2181140 + 66 NuclAT_48 - -
JMY44_RS10270 2181453..2181560 - 108 WP_000170926.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- 2181613..2181674 + 62 NuclAT_16 - Antitoxin
- 2181613..2181674 + 62 NuclAT_16 - Antitoxin
- 2181613..2181674 + 62 NuclAT_16 - Antitoxin
- 2181613..2181674 + 62 NuclAT_16 - Antitoxin
- 2181613..2181674 + 62 NuclAT_19 - Antitoxin
- 2181613..2181674 + 62 NuclAT_19 - Antitoxin
- 2181613..2181674 + 62 NuclAT_19 - Antitoxin
- 2181613..2181674 + 62 NuclAT_19 - Antitoxin
- 2181613..2181674 + 62 NuclAT_22 - Antitoxin
- 2181613..2181674 + 62 NuclAT_22 - Antitoxin
- 2181613..2181674 + 62 NuclAT_22 - Antitoxin
- 2181613..2181674 + 62 NuclAT_22 - Antitoxin
- 2181613..2181674 + 62 NuclAT_25 - Antitoxin
- 2181613..2181674 + 62 NuclAT_25 - Antitoxin
- 2181613..2181674 + 62 NuclAT_25 - Antitoxin
- 2181613..2181674 + 62 NuclAT_25 - Antitoxin
- 2181613..2181674 + 62 NuclAT_28 - Antitoxin
- 2181613..2181674 + 62 NuclAT_28 - Antitoxin
- 2181613..2181674 + 62 NuclAT_28 - Antitoxin
- 2181613..2181674 + 62 NuclAT_28 - Antitoxin
- 2181613..2181674 + 62 NuclAT_31 - Antitoxin
- 2181613..2181674 + 62 NuclAT_31 - Antitoxin
- 2181613..2181674 + 62 NuclAT_31 - Antitoxin
- 2181613..2181674 + 62 NuclAT_31 - Antitoxin
- 2181613..2181675 + 63 NuclAT_51 - -
- 2181613..2181675 + 63 NuclAT_51 - -
- 2181613..2181675 + 63 NuclAT_51 - -
- 2181613..2181675 + 63 NuclAT_51 - -
- 2181613..2181675 + 63 NuclAT_54 - -
- 2181613..2181675 + 63 NuclAT_54 - -
- 2181613..2181675 + 63 NuclAT_54 - -
- 2181613..2181675 + 63 NuclAT_54 - -
- 2181613..2181676 + 64 NuclAT_34 - -
- 2181613..2181676 + 64 NuclAT_34 - -
- 2181613..2181676 + 64 NuclAT_34 - -
- 2181613..2181676 + 64 NuclAT_34 - -
- 2181613..2181676 + 64 NuclAT_37 - -
- 2181613..2181676 + 64 NuclAT_37 - -
- 2181613..2181676 + 64 NuclAT_37 - -
- 2181613..2181676 + 64 NuclAT_37 - -
- 2181613..2181676 + 64 NuclAT_40 - -
- 2181613..2181676 + 64 NuclAT_40 - -
- 2181613..2181676 + 64 NuclAT_40 - -
- 2181613..2181676 + 64 NuclAT_40 - -
- 2181613..2181676 + 64 NuclAT_43 - -
- 2181613..2181676 + 64 NuclAT_43 - -
- 2181613..2181676 + 64 NuclAT_43 - -
- 2181613..2181676 + 64 NuclAT_43 - -
- 2181613..2181676 + 64 NuclAT_46 - -
- 2181613..2181676 + 64 NuclAT_46 - -
- 2181613..2181676 + 64 NuclAT_46 - -
- 2181613..2181676 + 64 NuclAT_46 - -
- 2181613..2181676 + 64 NuclAT_49 - -
- 2181613..2181676 + 64 NuclAT_49 - -
- 2181613..2181676 + 64 NuclAT_49 - -
- 2181613..2181676 + 64 NuclAT_49 - -
JMY44_RS10275 2181989..2182096 - 108 WP_074147554.1 type I toxin-antitoxin system toxin Ldr family protein -
- 2182144..2182209 + 66 NuclAT_14 - -
- 2182144..2182209 + 66 NuclAT_14 - -
- 2182144..2182209 + 66 NuclAT_14 - -
- 2182144..2182209 + 66 NuclAT_14 - -
- 2182144..2182209 + 66 NuclAT_17 - -
- 2182144..2182209 + 66 NuclAT_17 - -
- 2182144..2182209 + 66 NuclAT_17 - -
- 2182144..2182209 + 66 NuclAT_17 - -
- 2182144..2182209 + 66 NuclAT_20 - -
- 2182144..2182209 + 66 NuclAT_20 - -
- 2182144..2182209 + 66 NuclAT_20 - -
- 2182144..2182209 + 66 NuclAT_20 - -
- 2182144..2182209 + 66 NuclAT_23 - -
- 2182144..2182209 + 66 NuclAT_23 - -
- 2182144..2182209 + 66 NuclAT_23 - -
- 2182144..2182209 + 66 NuclAT_23 - -
- 2182144..2182209 + 66 NuclAT_26 - -
- 2182144..2182209 + 66 NuclAT_26 - -
- 2182144..2182209 + 66 NuclAT_26 - -
- 2182144..2182209 + 66 NuclAT_26 - -
- 2182144..2182209 + 66 NuclAT_29 - -
- 2182144..2182209 + 66 NuclAT_29 - -
- 2182144..2182209 + 66 NuclAT_29 - -
- 2182144..2182209 + 66 NuclAT_29 - -
- 2182144..2182211 + 68 NuclAT_32 - -
- 2182144..2182211 + 68 NuclAT_32 - -
- 2182144..2182211 + 68 NuclAT_32 - -
- 2182144..2182211 + 68 NuclAT_32 - -
- 2182144..2182211 + 68 NuclAT_35 - -
- 2182144..2182211 + 68 NuclAT_35 - -
- 2182144..2182211 + 68 NuclAT_35 - -
- 2182144..2182211 + 68 NuclAT_35 - -
- 2182144..2182211 + 68 NuclAT_38 - -
- 2182144..2182211 + 68 NuclAT_38 - -
- 2182144..2182211 + 68 NuclAT_38 - -
- 2182144..2182211 + 68 NuclAT_38 - -
- 2182144..2182211 + 68 NuclAT_41 - -
- 2182144..2182211 + 68 NuclAT_41 - -
- 2182144..2182211 + 68 NuclAT_41 - -
- 2182144..2182211 + 68 NuclAT_41 - -
- 2182144..2182211 + 68 NuclAT_44 - -
- 2182144..2182211 + 68 NuclAT_44 - -
- 2182144..2182211 + 68 NuclAT_44 - -
- 2182144..2182211 + 68 NuclAT_44 - -
- 2182144..2182211 + 68 NuclAT_47 - -
- 2182144..2182211 + 68 NuclAT_47 - -
- 2182144..2182211 + 68 NuclAT_47 - -
- 2182144..2182211 + 68 NuclAT_47 - -
- 2182145..2182210 + 66 NuclAT_52 - -
- 2182145..2182210 + 66 NuclAT_52 - -
- 2182145..2182210 + 66 NuclAT_52 - -
- 2182145..2182210 + 66 NuclAT_52 - -
- 2182145..2182210 + 66 NuclAT_55 - -
- 2182145..2182210 + 66 NuclAT_55 - -
- 2182145..2182210 + 66 NuclAT_55 - -
- 2182145..2182210 + 66 NuclAT_55 - -
JMY44_RS10280 2182501..2183601 - 1101 WP_001295620.1 sodium-potassium/proton antiporter ChaA -
JMY44_RS10285 2183871..2184101 + 231 WP_001146442.1 putative cation transport regulator ChaB -
JMY44_RS10290 2184259..2184954 + 696 WP_001297117.1 glutathione-specific gamma-glutamylcyclotransferase -
JMY44_RS10295 2184998..2185351 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3983.84 Da        Isoelectric Point: 11.6501

>T187336 WP_000170926.1 NZ_CP068591:c2181560-2181453 [Escherichia coli]
MTLAKFAMIFWHDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T187336 NZ_CP089781:3762203-3762460 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 62 bp

>AT187336 NZ_CP068591:2181613-2181674 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y1K9

Antitoxin

Download structure file

References