Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 29860..30517 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP068573 | ||
| Organism | Klebsiella pneumoniae strain IR1251 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | JJV77_RS26225 | Protein ID | WP_000270043.1 |
| Coordinates | 29860..30210 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JJV77_RS26230 | Protein ID | WP_000124640.1 |
| Coordinates | 30215..30517 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJV77_RS26180 | 25171..25350 | + | 180 | Protein_33 | helix-turn-helix transcriptional regulator | - |
| JJV77_RS26185 | 25415..26119 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| JJV77_RS26190 | 26334..26831 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| JJV77_RS26195 | 26834..27322 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| JJV77_RS26200 | 27419..27754 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| JJV77_RS26205 | 27769..28239 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| JJV77_RS26210 | 28232..28603 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| JJV77_RS26215 | 28614..28808 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| JJV77_RS26220 | 29149..29697 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| JJV77_RS26225 | 29860..30210 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JJV77_RS26230 | 30215..30517 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| JJV77_RS26235 | 30544..30837 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| JJV77_RS26240 | 30925..31197 | - | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| JJV77_RS26245 | 31255..31782 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| JJV77_RS26250 | 32013..32870 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| JJV77_RS26255 | 32857..33087 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| JJV77_RS26260 | 33087..33605 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| JJV77_RS26265 | 33602..34048 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| JJV77_RS26270 | 34048..34407 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| JJV77_RS26275 | 34464..34892 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / sul1 / qacE / dfrA25 / blaCMY-2 | - | 1..185118 | 185118 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T187322 WP_000270043.1 NZ_CP068573:29860-30210 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T187322 NZ_CP089781:2855362-2855775 [Mycobacterium tuberculosis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT187322 WP_000124640.1 NZ_CP068573:30215-30517 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT187322 NZ_CP089781:2855814-2856071 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|