Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4348145..4348920 Replicon chromosome
Accession NZ_CP068572
Organism Klebsiella pneumoniae strain IR1251

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag JJV77_RS21380 Protein ID WP_004150910.1
Coordinates 4348145..4348630 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag JJV77_RS21385 Protein ID WP_004150912.1
Coordinates 4348627..4348920 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJV77_RS21355 4343314..4344681 - 1368 WP_004150905.1 replicative DNA helicase -
JJV77_RS21360 4344674..4345057 - 384 WP_004150906.1 hypothetical protein -
JJV77_RS21365 4345057..4345929 - 873 WP_004188557.1 ParA family protein -
JJV77_RS21370 4346535..4346751 - 217 Protein_4191 transposase -
JJV77_RS21375 4346848..4347441 - 594 WP_004188553.1 hypothetical protein -
JJV77_RS21380 4348145..4348630 - 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
JJV77_RS21385 4348627..4348920 - 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
JJV77_RS21390 4349565..4350941 + 1377 WP_004217775.1 cystathionine beta-synthase -
JJV77_RS21395 4350952..4352100 + 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
JJV77_RS21400 4352101..4353012 - 912 WP_004188550.1 LysR family transcriptional regulator -
JJV77_RS21405 4353110..4353712 + 603 WP_002916735.1 short chain dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Integrative and Conjugative Element - - 4291125..4349171 58046
flank IS/Tn - - 4346599..4346751 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T187317 WP_004150910.1 NZ_CP068572:c4348630-4348145 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T187317 NZ_CP089781:2310739-2311149 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT187317 WP_004150912.1 NZ_CP068572:c4348920-4348627 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT187317 NZ_CP089781:2310513-2310746 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References