Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2237759..2238407 Replicon chromosome
Accession NZ_CP068562
Organism Morganella morganii strain FAM24681

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC794_RS10515 Protein ID WP_107679151.1
Coordinates 2237759..2238103 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC794_RS10520 Protein ID WP_107679152.1
Coordinates 2238108..2238407 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC794_RS10505 (JC794_10510) 2233359..2234456 + 1098 WP_107679149.1 efflux RND transporter periplasmic adaptor subunit -
JC794_RS10510 (JC794_10515) 2234453..2237542 + 3090 WP_107679150.1 efflux RND transporter permease subunit -
JC794_RS10515 (JC794_10520) 2237759..2238103 + 345 WP_107679151.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC794_RS10520 (JC794_10525) 2238108..2238407 + 300 WP_107679152.1 helix-turn-helix transcriptional regulator Antitoxin
JC794_RS10525 (JC794_10530) 2238461..2239333 - 873 WP_107679153.1 dimethyl sulfoxide reductase anchor subunit -
JC794_RS10530 (JC794_10535) 2239330..2239959 - 630 WP_107679154.1 dimethylsulfoxide reductase subunit B -
JC794_RS10535 (JC794_10540) 2239956..2242340 - 2385 WP_107679155.1 molybdopterin-dependent oxidoreductase -
JC794_RS10540 (JC794_10545) 2242706..2243194 - 489 WP_107679156.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13331.30 Da        Isoelectric Point: 8.8135

>T187299 WP_107679151.1 NZ_CP068562:2237759-2238103 [Morganella morganii]
VWTVLLTDYFNEWLSKQDTRMKEKVLASLGNLEIYGPVLTRPYVDTVKTSQYPNMKELRIWHAGRAIRAFFAFDPERQAI
ILCAGDKGKDKRFYQTMIRIADEQFSSYLSATQE

Download         Length: 345 bp

>T187299 NZ_CP089781:1164983-1165864 [Mycobacterium tuberculosis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11166.90 Da        Isoelectric Point: 7.0156

>AT187299 WP_107679152.1 NZ_CP068562:2238108-2238407 [Morganella morganii]
MKTLQEVIAAQSPESRERIKQLTDELVLETGLQLLREELHISQKTLANNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRIFRV

Download         Length: 300 bp

>AT187299 NZ_CP089781:1164363-1164986 [Mycobacterium tuberculosis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References