Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1738646..1739304 Replicon chromosome
Accession NZ_CP068562
Organism Morganella morganii strain FAM24681

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JC794_RS07900 Protein ID WP_107678433.1
Coordinates 1738646..1738999 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JC794_RS07905 Protein ID WP_046892450.1
Coordinates 1739002..1739304 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JC794_RS07890 (JC794_07885) 1736825..1737082 - 258 WP_107678432.1 biofilm formation regulator BssS -
JC794_RS07895 (JC794_07890) 1737317..1738369 - 1053 WP_107678459.1 dihydroorotase -
JC794_RS07900 (JC794_07895) 1738646..1738999 + 354 WP_107678433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JC794_RS07905 (JC794_07900) 1739002..1739304 + 303 WP_046892450.1 XRE family transcriptional regulator Antitoxin
JC794_RS07930 (JC794_07925) 1740431..1740940 - 510 WP_107678434.1 YlaC family protein -
JC794_RS07935 (JC794_07930) 1741398..1741610 + 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
JC794_RS07940 (JC794_07935) 1741714..1741908 + 195 WP_046892448.1 protein DsrB -
JC794_RS07945 (JC794_07940) 1742260..1742955 + 696 WP_046892447.1 MgtC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13412.31 Da        Isoelectric Point: 9.7296

>T187298 WP_107678433.1 NZ_CP068562:1738646-1738999 [Morganella morganii]
VWKIITTDNFAAWFAAQDDGDRTAILAAMLVLEKTGPGLSGPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

>T187298 NZ_CP089781:1012166-1012600 [Mycobacterium tuberculosis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.93 Da        Isoelectric Point: 8.5490

>AT187298 WP_046892450.1 NZ_CP068562:1739002-1739304 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVNKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp

>AT187298 NZ_CP089781:1011981-1012160 [Mycobacterium tuberculosis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCATGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References