Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 2637741..2638390 Replicon chromosome
Accession NZ_CP068551
Organism Pseudomonas khazarica strain ODT-83

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JLK41_RS12650 Protein ID WP_047588122.1
Coordinates 2638046..2638390 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JLK41_RS12645 Protein ID WP_124148941.1
Coordinates 2637741..2638049 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLK41_RS12620 (JLK41_12620) 2632844..2633158 - 315 WP_014851536.1 c-type cytochrome -
JLK41_RS12625 (JLK41_12625) 2633446..2634030 - 585 WP_080757027.1 TSUP family transporter -
JLK41_RS12630 (JLK41_12630) 2634111..2635316 + 1206 WP_196250622.1 chromate efflux transporter -
JLK41_RS12635 (JLK41_12635) 2635327..2635632 + 306 WP_047588115.1 PadR family transcriptional regulator -
JLK41_RS12640 (JLK41_12640) 2635795..2637225 + 1431 WP_210391153.1 IS1182-like element ISPa7 family transposase -
JLK41_RS12645 (JLK41_12645) 2637741..2638049 - 309 WP_124148941.1 transcriptional regulator Antitoxin
JLK41_RS12650 (JLK41_12650) 2638046..2638390 - 345 WP_047588122.1 toxin Toxin
JLK41_RS12655 (JLK41_12655) 2638548..2639474 - 927 WP_210391154.1 LysR family transcriptional regulator -
JLK41_RS12660 (JLK41_12660) 2639488..2640687 - 1200 WP_210391155.1 MFS transporter -
JLK41_RS12665 (JLK41_12665) 2640773..2642626 - 1854 WP_210391156.1 asparagine synthase (glutamine-hydrolyzing) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2595232..2672813 77581
- flank IS/Tn - - 2635795..2637225 1430


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(42-92)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13366.33 Da        Isoelectric Point: 10.2892

>T187259 WP_047588122.1 NZ_CP068551:c2638390-2638046 [Pseudomonas khazarica]
MKALFVELSPFERNRKAHLDDDEYSLFQQMLLTNPEAGAVIANSGGLRKVRFGSVRRNKGKRGGVRVIYYYWLRGLQFWL
FTLYDKDELDDLSSDQRRQLKALLEREVKARQAP

Download         Length: 345 bp

>T187259 NZ_CP089780:c2364634-2364200 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11579.35 Da        Isoelectric Point: 10.0926

>AT187259 WP_124148941.1 NZ_CP068551:c2638049-2637741 [Pseudomonas khazarica]
MTKRDIFSELIEGFDDLAAAREGKRTLRTQKVEYKPIEPATGAEIVALREKLQMSQGVFAQAIHAKPATLKNWEQNRSKP
NDQATVLIRILNKHPDLIRELA

Download         Length: 309 bp

>AT187259 NZ_CP089780:c2364895-2364641 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References