Detailed information of TA system TA187256

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 3091170..3091683
• Replicon: chromosome
• Accession: NZ_CP068547
• Organism: Tamlana sp. s12

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2I7SMP3
• Locus tag: JJL45_RS13345
• Protein ID: WP_068602076.1
• Coordinates: 3091170..3091427 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JJL45_RS13350
• Protein ID: WP_068602074.1
• Coordinates: 3091429..3091683 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJL45_RS13325	3086231..3087514	+	1284	WP_202664166.1	hypothetical protein	-
JJL45_RS13330	3087536..3087973	+	438	WP_202664167.1	hypothetical protein	-
JJL45_RS13335	3088336..3089529	-	1194	WP_067146010.1	ADP-forming succinate--CoA ligase subunit beta	-
JJL45_RS13340	3089723..3090958	+	1236	WP_068602078.1	diaminopimelate decarboxylase	-
JJL45_RS13345	3091170..3091427	-	258	WP_068602076.1	Txe/YoeB family addiction module toxin	Toxin
JJL45_RS13350	3091429..3091683	-	255	WP_068602074.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JJL45_RS13355	3091768..3092340	-	573	WP_082935874.1	hypothetical protein	-
JJL45_RS13360	3092456..3093313	-	858	WP_067145999.1	phosphate--nucleotide phosphotransferase	-
JJL45_RS13365	3093450..3094223	+	774	WP_068602070.1	hypothetical protein	-
JJL45_RS13370	3094308..3095471	-	1164	WP_068602068.1	sigma-54 dependent transcriptional regulator	-
JJL45_RS13375	3095507..3096436	-	930	WP_082935853.1	mechanosensitive ion channel	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10558.13 Da
• Isoelectric Point: 9.2411

>T187256 WP_068602076.1 NZ_CP068547:c3091427-3091170 [Tamlana sp. s12]
MKYIFVDESWEDYLYWQKTDKKKLKKINELLKDIARNPFDGVGKPEPLKHKYAGFWSRRIDSEHRLIYQYREDEILIAKC
RFHYD

Nucleotide

• Length: 258 bp

>T187256 NZ_CP089780:c2226969-2226625 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9535.96 Da
• Isoelectric Point: 9.6242

>AT187256 WP_068602074.1 NZ_CP068547:c3091683-3091429 [Tamlana sp. s12]
MLITTVSDFRKDIKSYLDRVVKNFETLIINRGKDSGIVVMSLQEYNSLMATNHELSSRKNELRLDSAINKLKNGTAFSKD
LIEG

Nucleotide

• Length: 255 bp

>AT187256 NZ_CP089780:c2227211-2226963 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Structures

Toxin

• AlphaFold DB: A0A2I7SMP3