Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 330020..330671 Replicon plasmid unnamed3
Accession NZ_CP068443
Organism Pantoea agglomerans strain ZJU23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JK642_RS22380 Protein ID WP_069026837.1
Coordinates 330020..330364 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JK642_RS22385 Protein ID WP_069026836.1
Coordinates 330357..330671 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK642_RS22360 (JK642_22300) 326353..326823 + 471 WP_031594134.1 GNAT family N-acetyltransferase -
JK642_RS22365 (JK642_22305) 326927..327805 + 879 WP_033768811.1 23S rRNA pseudouridine(2604) synthase RluF -
JK642_RS22370 (JK642_22310) 327863..328921 - 1059 WP_115758171.1 SDR family oxidoreductase -
JK642_RS22375 (JK642_22315) 329019..329930 + 912 WP_115758077.1 LysR family transcriptional regulator -
JK642_RS22380 (JK642_22320) 330020..330364 + 345 WP_069026837.1 toxin Toxin
JK642_RS22385 (JK642_22325) 330357..330671 + 315 WP_069026836.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JK642_RS22390 (JK642_22330) 330881..331552 + 672 WP_235765305.1 hypothetical protein -
JK642_RS22395 (JK642_22335) 331643..332494 - 852 WP_235765306.1 Vmh family MBL fold metallo-hydrolase -
JK642_RS22400 (JK642_22340) 332640..333521 + 882 WP_235765307.1 LysR family transcriptional regulator -
JK642_RS22405 (JK642_22345) 333560..333979 + 420 WP_031594127.1 VOC family protein -
JK642_RS22410 (JK642_22350) 334467..334769 + 303 WP_235765308.1 type 1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - iroN 1..567588 567588


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin MqsA/HigA-2

(18-100)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13486.26 Da        Isoelectric Point: 9.6381

>T187237 WP_069026837.1 NZ_CP068443:330020-330364 [Pantoea agglomerans]
MDALFIELSSFQKYRADYLNDDQYRLFQNMLLADPEKGDVIPDTGGLRKVRFRDERRHKGARGGIRVIYYWTNTQGQFIL
FTIYDKDQRDDLTRQQRDALATALNVIKKGLRHD

Download         Length: 345 bp

>T187237 NZ_CP089780:c754757-754320 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12022.84 Da        Isoelectric Point: 9.8806

>AT187237 WP_069026836.1 NZ_CP068443:330357-330671 [Pantoea agglomerans]
MTERDIFSELMTGMQELKDHQEGKITLKSYKVTKRAPVTIAPQELRDVREKLNLSQAVFAHYLHTGETTYQNWEQGRARP
NAQAVLLIRMVQQNPETLKTLAKL

Download         Length: 315 bp

>AT187237 NZ_CP089780:c754210-753965 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References