187233

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2577333..2578663 Replicon chromosome
Accession NZ_CP068440
Organism Pantoea agglomerans strain ZJU23

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag JK642_RS12050 Protein ID WP_235764371.1
Coordinates 2577641..2578663 (+) Length 341 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag JK642_RS12045 Protein ID WP_031591302.1
Coordinates 2577333..2577644 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK642_RS12020 (JK642_12005) 2572800..2574182 + 1383 WP_235764368.1 D-arabinono-1,4-lactone oxidase -
JK642_RS12025 (JK642_12010) 2574195..2575025 + 831 WP_235764369.1 glycosyltransferase family 8 protein -
JK642_RS12030 (JK642_12015) 2575116..2576237 - 1122 WP_235764370.1 Gfo/Idh/MocA family oxidoreductase -
JK642_RS12040 (JK642_12025) 2577013..2577348 + 336 WP_143990366.1 XRE family transcriptional regulator -
JK642_RS12045 (JK642_12030) 2577333..2577644 + 312 WP_031591302.1 HipA N-terminal domain-containing protein Antitoxin
JK642_RS12050 (JK642_12035) 2577641..2578663 + 1023 WP_235764371.1 HipA domain-containing protein Toxin
JK642_RS12055 (JK642_12040) 2578789..2581008 - 2220 WP_083068992.1 catalase/peroxidase HPI -
JK642_RS12060 2581196..2581378 - 183 Protein_2365 hypothetical protein -
JK642_RS12065 (JK642_12045) 2581495..2582517 - 1023 WP_010247994.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(58-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 341 a.a.        Molecular weight: 38609.23 Da        Isoelectric Point: 6.8348

>T187233 WP_235764371.1 NZ_CP068440:2577641-2578663 [Pantoea agglomerans]
MNSERCLITLKRLKESELKTGYSTKGIRHLLGSLNVALSLPFTRSQFIQELPERQKGMSISGYQPKLSLRLEKGELVVVS
NDGTYILKPSPEEYPHLAENEHATMCVMQRLKFDVPPFGLMPFRHDENRPDELAFVIKRYDRTASDNARLHQEQLDGAMG
LGDKYGRIDNHKAISYEKAAKFLKTRVNSSLKSKRDLFLRIVYAYVLGNNDFHLRNIGIILPPQGSPWLAPVYDFISVVP
YPAAFGEYLALPLLEREENDAGNAPGMNSEYGEYLGADFILLAQGMDINPTLARKWLSEVVSHHQLIIDTYNESHMPESQ
REAVLDYVARRITLLAVTEI

Download         Length: 1023 bp

>T187233 NZ_CP089780:715096-715491 [Mycobacterium tuberculosis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11696.49 Da        Isoelectric Point: 4.7953

>AT187233 WP_031591302.1 NZ_CP068440:2577333-2577644 [Pantoea agglomerans]
MARKIEVWLYNTLAGTLSEGQNGYTFCYLPTYVGCAISLSMPVRPEPYLSEELHPFFKGLAPEGWLRKRYSEIQKIDDKD
LFGLLMENGNDLLGAVVFKEITS

Download         Length: 312 bp

>AT187233 NZ_CP089780:714842-715096 [Mycobacterium tuberculosis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References