Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2561982..2562642 Replicon chromosome
Accession NZ_CP068440
Organism Pantoea agglomerans strain ZJU23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JK642_RS11975 Protein ID WP_115759198.1
Coordinates 2562289..2562642 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JK642_RS11970 Protein ID WP_010247918.1
Coordinates 2561982..2562284 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK642_RS11950 (JK642_11935) 2557821..2558846 - 1026 WP_181016808.1 ABC transporter permease -
JK642_RS11955 (JK642_11940) 2558870..2560354 - 1485 WP_039389407.1 sugar ABC transporter ATP-binding protein -
JK642_RS11960 (JK642_11945) 2560387..2561310 - 924 WP_031591254.1 sugar ABC transporter substrate-binding protein -
JK642_RS11970 (JK642_11955) 2561982..2562284 - 303 WP_010247918.1 XRE family transcriptional regulator Antitoxin
JK642_RS11975 (JK642_11960) 2562289..2562642 - 354 WP_115759198.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JK642_RS11980 (JK642_11965) 2562941..2564029 - 1089 WP_115759199.1 YncE family protein -
JK642_RS11985 (JK642_11970) 2564424..2566586 + 2163 WP_235764366.1 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
JK642_RS11990 (JK642_11975) 2566714..2566986 - 273 WP_083068971.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13743.86 Da        Isoelectric Point: 8.4949

>T187232 WP_115759198.1 NZ_CP068440:c2562642-2562289 [Pantoea agglomerans]
VWMIKTTERFDRWFTLLNESDRACVLAALIVLREKEPGLSRPYADTLKGSVYINMKELRIQSRGDPIRAFFAFDPNRTAI
VLCAGNKVGNEKRFYREMLPVADREFTHWLNVFKDEE

Download         Length: 354 bp

>T187232 NZ_CP089780:709438-709839 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10941.72 Da        Isoelectric Point: 5.7251

>AT187232 WP_010247918.1 NZ_CP068440:c2562284-2561982 [Pantoea agglomerans]
MGRTLEQLIADEKPEVVADAQAMATDILLNIHLAELREKVQKTQVEMAKALGITQPTVAGMEKPGRDLKLSTLKRYIDAA
GGKLRLVVELPDGSHYGFEV

Download         Length: 303 bp

>AT187232 NZ_CP089780:709214-709441 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References