Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
Location | 294983..295628 | Replicon | chromosome |
Accession | NZ_CP068440 | ||
Organism | Pantoea agglomerans strain ZJU23 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | JK642_RS01350 | Protein ID | WP_033787535.1 |
Coordinates | 294983..295336 (+) | Length | 118 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | JK642_RS01355 | Protein ID | WP_022625233.1 |
Coordinates | 295329..295628 (+) | Length | 100 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JK642_RS01330 (JK642_01330) | 290839..291804 | - | 966 | WP_064704971.1 | AraC family transcriptional regulator | - |
JK642_RS01335 (JK642_01335) | 291909..293096 | + | 1188 | WP_010252123.1 | MFS transporter | - |
JK642_RS01340 (JK642_01340) | 293309..293518 | + | 210 | WP_009092571.1 | DUF1471 domain-containing protein | - |
JK642_RS01345 (JK642_01345) | 293721..294773 | + | 1053 | WP_182687216.1 | YncE family protein | - |
JK642_RS01350 (JK642_01350) | 294983..295336 | + | 354 | WP_033787535.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
JK642_RS01355 (JK642_01355) | 295329..295628 | + | 300 | WP_022625233.1 | helix-turn-helix transcriptional regulator | Antitoxin |
JK642_RS01360 (JK642_01360) | 295676..296917 | - | 1242 | WP_010672044.1 | peptide antibiotic transporter SbmA | - |
JK642_RS01365 (JK642_01365) | 297194..297928 | + | 735 | WP_069025646.1 | gluconate 2-dehydrogenase subunit 3 family protein | - |
JK642_RS01370 (JK642_01370) | 297931..299715 | + | 1785 | WP_182687220.1 | GMC family oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | - | 285362..295628 | 10266 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 118 a.a. Molecular weight: 13421.31 Da Isoelectric Point: 6.4741
>T187228 WP_033787535.1 NZ_CP068440:294983-295336 [Pantoea agglomerans]
MWDVDTTKRFDEWFKAQTEELKEDMLAAIVILSEYGPHLARPFADTVDGSDFPNMKELRVQHQGKPIRAFFAFDPSRRGI
VLCAGDKTGVKEKKFYKDMIKLADAEFRKYLNGGDNG
MWDVDTTKRFDEWFKAQTEELKEDMLAAIVILSEYGPHLARPFADTVDGSDFPNMKELRVQHQGKPIRAFFAFDPSRRGI
VLCAGDKTGVKEKKFYKDMIKLADAEFRKYLNGGDNG
Download Length: 354 bp
>T187228 NZ_CP089780:676352-676759 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA
Antitoxin
Download Length: 100 a.a. Molecular weight: 11131.98 Da Isoelectric Point: 9.8103
>AT187228 WP_022625233.1 NZ_CP068440:295329-295628 [Pantoea agglomerans]
MANLKELMANQSPESRERIAKKVDAMRQVIALHMLREELNLSQTEMAHAMGVKQPTIARMEQADNDPRLSTLKRYVTALG
GEISIDVKLPTGKRIAFDL
MANLKELMANQSPESRERIAKKVDAMRQVIALHMLREELNLSQTEMAHAMGVKQPTIARMEQADNDPRLSTLKRYVTALG
GEISIDVKLPTGKRIAFDL
Download Length: 300 bp
>AT187228 NZ_CP089780:676140-676355 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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