Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 294983..295628 Replicon chromosome
Accession NZ_CP068440
Organism Pantoea agglomerans strain ZJU23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JK642_RS01350 Protein ID WP_033787535.1
Coordinates 294983..295336 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JK642_RS01355 Protein ID WP_022625233.1
Coordinates 295329..295628 (+) Length 100 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK642_RS01330 (JK642_01330) 290839..291804 - 966 WP_064704971.1 AraC family transcriptional regulator -
JK642_RS01335 (JK642_01335) 291909..293096 + 1188 WP_010252123.1 MFS transporter -
JK642_RS01340 (JK642_01340) 293309..293518 + 210 WP_009092571.1 DUF1471 domain-containing protein -
JK642_RS01345 (JK642_01345) 293721..294773 + 1053 WP_182687216.1 YncE family protein -
JK642_RS01350 (JK642_01350) 294983..295336 + 354 WP_033787535.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JK642_RS01355 (JK642_01355) 295329..295628 + 300 WP_022625233.1 helix-turn-helix transcriptional regulator Antitoxin
JK642_RS01360 (JK642_01360) 295676..296917 - 1242 WP_010672044.1 peptide antibiotic transporter SbmA -
JK642_RS01365 (JK642_01365) 297194..297928 + 735 WP_069025646.1 gluconate 2-dehydrogenase subunit 3 family protein -
JK642_RS01370 (JK642_01370) 297931..299715 + 1785 WP_182687220.1 GMC family oxidoreductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 285362..295628 10266


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-107)

Antitoxin

(12-88)


Sequences


Toxin        


Download         Length: 118 a.a.        Molecular weight: 13421.31 Da        Isoelectric Point: 6.4741

>T187228 WP_033787535.1 NZ_CP068440:294983-295336 [Pantoea agglomerans]
MWDVDTTKRFDEWFKAQTEELKEDMLAAIVILSEYGPHLARPFADTVDGSDFPNMKELRVQHQGKPIRAFFAFDPSRRGI
VLCAGDKTGVKEKKFYKDMIKLADAEFRKYLNGGDNG

Download         Length: 354 bp

>T187228 NZ_CP089780:676352-676759 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11131.98 Da        Isoelectric Point: 9.8103

>AT187228 WP_022625233.1 NZ_CP068440:295329-295628 [Pantoea agglomerans]
MANLKELMANQSPESRERIAKKVDAMRQVIALHMLREELNLSQTEMAHAMGVKQPTIARMEQADNDPRLSTLKRYVTALG
GEISIDVKLPTGKRIAFDL

Download         Length: 300 bp

>AT187228 NZ_CP089780:676140-676355 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References