Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1459928..1460521 Replicon chromosome
Accession NZ_CP068434
Organism Cupriavidus necator isolate XXL

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JJQ59_RS06865 Protein ID WP_114130448.1
Coordinates 1460243..1460521 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JJQ59_RS06860 Protein ID WP_114130415.1
Coordinates 1459928..1460230 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJQ59_RS06835 1455759..1458206 + 2448 WP_114130413.1 phenylalanine--tRNA ligase subunit beta -
JJQ59_RS06840 1458297..1458707 + 411 WP_022534405.1 integration host factor subunit alpha -
JJQ59_RS06845 1458824..1459249 + 426 WP_013956331.1 MerR family transcriptional regulator -
JJQ59_RS06855 1459524..1459835 + 312 WP_114130414.1 hypothetical protein -
JJQ59_RS06860 1459928..1460230 - 303 WP_114130415.1 HigA family addiction module antidote protein Antitoxin
JJQ59_RS06865 1460243..1460521 - 279 WP_114130448.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJQ59_RS06870 1460840..1461346 - 507 WP_114130416.1 cupin domain-containing protein -
JJQ59_RS06875 1461390..1461650 - 261 WP_035817461.1 hypothetical protein -
JJQ59_RS06880 1461877..1462263 + 387 WP_114130417.1 hypothetical protein -
JJQ59_RS06885 1462298..1462537 + 240 WP_114130418.1 hypothetical protein -
JJQ59_RS06890 1462629..1462817 + 189 WP_018310329.1 hypothetical protein -
JJQ59_RS06895 1462919..1463278 + 360 WP_114130419.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-66)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10420.88 Da        Isoelectric Point: 7.8109

>T187221 WP_114130448.1 NZ_CP068434:c1460521-1460243 [Cupriavidus necator]
MITSFNCRDTALLFAGTRIARFVNIESVAMRKLQQLHAAGDLSFLRVPPGNRLEALQGDRAGQHSIRFNDQWRICFCFAN
GHATDVEIVDYH

Download         Length: 279 bp

>T187221 NZ_CP089779:c4187169-4186768 [Mycobacterium tuberculosis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11037.76 Da        Isoelectric Point: 6.4670

>AT187221 WP_114130415.1 NZ_CP068434:c1460230-1459928 [Cupriavidus necator]
MAREVPLATPGEILQLDWLDPLGISQYALAKAIDVPPRRINEIVKGGRAITADTAVRLGAFFGTDPQGWMNLQTHFDTEM
AKEKIGEKKLESIRQHAVLA

Download         Length: 303 bp

>AT187221 NZ_CP089779:c4187401-4187162 [Mycobacterium tuberculosis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGCAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References