Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 226209..226935 Replicon chromosome
Accession NZ_CP068434
Organism Cupriavidus necator isolate XXL

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag JJQ59_RS01125 Protein ID WP_114131096.1
Coordinates 226209..226505 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag JJQ59_RS01130 Protein ID WP_114131097.1
Coordinates 226537..226935 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJQ59_RS01105 221783..222631 + 849 WP_114131092.1 thioesterase family protein -
JJQ59_RS01110 222645..223904 - 1260 WP_114131093.1 muropeptide transporter -
JJQ59_RS01115 224055..225017 + 963 WP_114131094.1 M48 family metallopeptidase -
JJQ59_RS01120 225088..226035 - 948 WP_114131095.1 N-acetyl-gamma-glutamyl-phosphate reductase -
JJQ59_RS01125 226209..226505 + 297 WP_114131096.1 type II toxin-antitoxin system MqsR family toxin Toxin
JJQ59_RS01130 226537..226935 + 399 WP_114131097.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
JJQ59_RS01135 226945..227721 - 777 WP_114131098.1 exodeoxyribonuclease III -
JJQ59_RS01140 227749..228435 + 687 WP_114131099.1 orotate phosphoribosyltransferase -
JJQ59_RS01145 228538..229845 + 1308 WP_114131100.1 patatin-like phospholipase family protein -
JJQ59_RS01150 229869..230678 - 810 WP_114131101.1 polyphosphate kinase 2 family protein -
JJQ59_RS01155 230786..231652 - 867 WP_114131102.1 diaminopimelate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-96)

Antitoxin

Antitoxin MqsA/HigA-2

(1-130)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11302.20 Da        Isoelectric Point: 9.3056

>T187220 WP_114131096.1 NZ_CP068434:226209-226505 [Cupriavidus necator]
MEKGTAHYRLWDVKALLAAGKMEMTFAAYSHAAMMGLRWSGVREILMQLGPADFYKNMTTYEDHRVWQDVYRPVTPQGAL
YVKLTVTDEVLVVSFKLR

Download         Length: 297 bp

>T187220 NZ_CP089779:c3892466-3892164 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14660.91 Da        Isoelectric Point: 7.6326

>AT187220 WP_114131097.1 NZ_CP068434:226537-226935 [Cupriavidus necator]
MKCPVCGGADLEAGIRDMPYTYRGETTVIRNVPGQWCPKCGEGVLPRDSDWVSDAMLAFNKQVNASLVDPAYITDVRKKL
RLDQREAAEIFGGGVNAFSRYETGRTKPPLALVKLLKLLDRHPELLEEIRAA

Download         Length: 399 bp

>AT187220 NZ_CP089779:c3892690-3892463 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGATGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References