Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1356293..1356857 Replicon chromosome
Accession NZ_CP068416
Organism Lacticaseibacillus paracasei subsp. tolerans strain S-NB

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag JK384_RS06820 Protein ID WP_016363448.1
Coordinates 1356555..1356857 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag JK384_RS06815 Protein ID WP_003570051.1
Coordinates 1356293..1356562 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK384_RS06785 1351298..1352185 - 888 WP_003570041.1 ABC transporter ATP-binding protein -
JK384_RS06790 1352382..1353608 - 1227 WP_003570043.1 hypothetical protein -
JK384_RS06795 1353806..1354210 + 405 WP_003570045.1 MerR family transcriptional regulator -
JK384_RS06800 1354203..1354529 + 327 WP_003584272.1 YrdB family protein -
JK384_RS06805 1354592..1355221 + 630 WP_003570047.1 DUF2399 domain-containing protein -
JK384_RS06810 1355266..1355919 + 654 WP_003570049.1 GNAT family N-acetyltransferase -
JK384_RS06815 1356293..1356562 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JK384_RS06820 1356555..1356857 + 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
JK384_RS06825 1357196..1357339 + 144 WP_162259784.1 hypothetical protein -
JK384_RS06830 1357457..1358149 + 693 WP_003570055.1 hypothetical protein -
JK384_RS06835 1358385..1360562 + 2178 WP_003570057.1 RNA-binding transcriptional accessory protein -
JK384_RS06840 1360987..1361544 - 558 WP_003584278.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T187216 WP_016363448.1 NZ_CP068416:1356555-1356857 [Lacticaseibacillus paracasei subsp. tolerans]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T187216 NZ_CP089779:3615402-3615815 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT187216 WP_003570051.1 NZ_CP068416:1356293-1356562 [Lacticaseibacillus paracasei subsp. tolerans]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT187216 NZ_CP089779:3615139-3615405 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References