187213

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1356294..1356858 Replicon chromosome
Accession NZ_CP068408
Organism Lacticaseibacillus paracasei subsp. tolerans strain S-NA5

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag JK381_RS06815 Protein ID WP_016363448.1
Coordinates 1356556..1356858 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag JK381_RS06810 Protein ID WP_003570051.1
Coordinates 1356294..1356563 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JK381_RS06780 1351299..1352186 - 888 WP_003570041.1 ABC transporter ATP-binding protein -
JK381_RS06785 1352383..1353609 - 1227 WP_003570043.1 hypothetical protein -
JK381_RS06790 1353807..1354211 + 405 WP_003570045.1 MerR family transcriptional regulator -
JK381_RS06795 1354204..1354530 + 327 WP_003584272.1 YrdB family protein -
JK381_RS06800 1354593..1355222 + 630 WP_003570047.1 DUF2399 domain-containing protein -
JK381_RS06805 1355267..1355920 + 654 WP_003570049.1 GNAT family N-acetyltransferase -
JK381_RS06810 1356294..1356563 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JK381_RS06815 1356556..1356858 + 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
JK381_RS06820 1357197..1357340 + 144 WP_162259784.1 hypothetical protein -
JK381_RS06825 1357458..1358150 + 693 WP_003570055.1 hypothetical protein -
JK381_RS06830 1358386..1360563 + 2178 WP_003570057.1 RNA-binding transcriptional accessory protein -
JK381_RS06835 1360988..1361545 - 558 WP_003584278.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T187213 WP_016363448.1 NZ_CP068408:1356556-1356858 [Lacticaseibacillus paracasei subsp. tolerans]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T187213 NZ_CP089779:3558477-3558890 [Mycobacterium tuberculosis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT187213 WP_003570051.1 NZ_CP068408:1356294-1356563 [Lacticaseibacillus paracasei subsp. tolerans]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT187213 NZ_CP089779:3558244-3558480 [Mycobacterium tuberculosis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References