Detailed information of TA system TA187188

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 15463..15721
• Replicon: chromosome
• Accession: NZ_CP068394
• Organism: Escherichia coli strain M-17

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: JK368_RS00075
• Protein ID: WP_000809168.1
• Coordinates: 15463..15615 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	15664..15721 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JK368_RS00055	10708..11421	-	714	WP_001102393.1	acidic protein MsyB	-
JK368_RS00060	11447..11851	-	405	WP_000843692.1	DUF2541 family protein	-
JK368_RS00065	12223..14139	+	1917	WP_000516135.1	molecular chaperone DnaK	-
JK368_RS00070	14228..15358	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
JK368_RS00075	15463..15615	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	15664..15721	+	58	-	-	Antitoxin
JK368_RS00080	16230..16991	+	762	WP_001274832.1	hypothetical protein	-
JK368_RS00085	17011..18504	+	1494	WP_001350365.1	sulfatase-like hydrolase/transferase	-
JK368_RS00090	18633..19892	+	1260	WP_000494929.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T187188 WP_000809168.1 NZ_CP068394:c15615-15463 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T187188 NZ_CP089779:2035738-2036157 [Mycobacterium tuberculosis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT187188 NZ_CP068394:15664-15721 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin