Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4292361..4293015 Replicon chromosome
Accession NZ_CP068390
Organism Pseudomonas chlororaphis subsp. aurantiaca strain YS21

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JHW28_RS19235 Protein ID WP_202340144.1
Coordinates 4292361..4292711 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JHW28_RS19240 Protein ID WP_025804712.1
Coordinates 4292701..4293015 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW28_RS19225 4289110..4290642 + 1533 WP_009049790.1 NADH-quinone oxidoreductase subunit M -
JHW28_RS19230 4290650..4292113 + 1464 WP_009044594.1 NADH-quinone oxidoreductase subunit NuoN -
JHW28_RS19235 4292361..4292711 + 351 WP_202340144.1 toxin Toxin
JHW28_RS19240 4292701..4293015 + 315 WP_025804712.1 transcriptional regulator Antitoxin
JHW28_RS19245 4293196..4294938 - 1743 WP_038577823.1 ABC transporter substrate-binding protein -
JHW28_RS19250 4294989..4295261 - 273 WP_038577821.1 DUF2160 domain-containing protein -
JHW28_RS19255 4295272..4296072 - 801 WP_038577819.1 carbohydrate ABC transporter permease -
JHW28_RS19260 4296084..4296950 - 867 WP_038577816.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-100)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13812.77 Da        Isoelectric Point: 8.5186

>T187186 WP_202340144.1 NZ_CP068390:4292361-4292711 [Pseudomonas chlororaphis subsp. aurantiaca]
MDALFIELPPFQRHRQDYLDDELFHSLQLELLKAPEAGDLIEGTGGLRKIRFVDERRHKGKRGGIRVIYYWWSGGAQFWL
FTLYAKNEQNDLTPHQKKLLKQLLNREVEVRTHHET

Download         Length: 351 bp

>T187186 NZ_CP089779:2026921-2027265 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11891.81 Da        Isoelectric Point: 10.7886

>AT187186 WP_025804712.1 NZ_CP068390:4292701-4293015 [Pseudomonas chlororaphis subsp. aurantiaca]
MKRDIFSELVEGFDALAKERQGKLTLRTHKVKLNALLPITAEEVLAVREQLNLSRSVFAMYLRTNTRTLENWEQGRAKPN
AQATTLIRLVQRFPDTVERLAALA

Download         Length: 315 bp

>AT187186 NZ_CP089779:2026679-2026927 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References