Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3408209..3408936 Replicon chromosome
Accession NZ_CP068287
Organism Enterobacter hormaechei strain 1575

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JJL14_RS16425 Protein ID WP_063147977.1
Coordinates 3408209..3408520 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JJL14_RS16430 Protein ID WP_063147976.1
Coordinates 3408517..3408936 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL14_RS16395 3403850..3404629 - 780 WP_088581799.1 acetolactate decarboxylase -
JJL14_RS16400 3404735..3405631 + 897 WP_063147979.1 LysR family transcriptional regulator -
JJL14_RS16405 3405859..3406071 - 213 WP_022647355.1 RNA chaperone/antiterminator CspA -
JJL14_RS16410 3406788..3406895 + 108 WP_157843337.1 ash family protein -
JJL14_RS16415 3406922..3407377 + 456 WP_063147978.1 hypothetical protein -
JJL14_RS16420 3407578..3407988 + 411 WP_023299534.1 ASCH domain-containing protein -
JJL14_RS16425 3408209..3408520 + 312 WP_063147977.1 type II toxin-antitoxin system HigB family toxin Toxin
JJL14_RS16430 3408517..3408936 + 420 WP_063147976.1 helix-turn-helix domain-containing protein Antitoxin
JJL14_RS16435 3409204..3409650 - 447 WP_063147975.1 hypothetical protein -
JJL14_RS16440 3409650..3410264 - 615 WP_063147974.1 hypothetical protein -
JJL14_RS16445 3410353..3410733 - 381 WP_045309197.1 hypothetical protein -
JJL14_RS16450 3411090..3411494 - 405 WP_063147973.1 SMI1/KNR4 family protein -
JJL14_RS16455 3411702..3412235 - 534 Protein_3213 nuclease -
JJL14_RS16460 3412247..3412692 - 446 Protein_3214 hypothetical protein -
JJL14_RS16465 3412778..3413080 - 303 WP_063147972.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-134)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12542.46 Da        Isoelectric Point: 10.0930

>T187144 WP_063147977.1 NZ_CP068287:3408209-3408520 [Enterobacter hormaechei]
MPAVSRAPFDAATRHFPIQELALEDLYWVLKGEHYPSPDDMRKRFPSRERMKYREKWWVIDVGGGHLRVMFFADFERRKI
FIKHISTHADYDKLTDLYRRKKE

Download         Length: 312 bp

>T187144 NZ_CP089778:c2416356-2416039 [Mycobacterium tuberculosis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15507.54 Da        Isoelectric Point: 4.7722

>AT187144 WP_063147976.1 NZ_CP068287:3408517-3408936 [Enterobacter hormaechei]
MNYSAAIKAANDLTRELPFLGSSPSRQDYEDAMGLVEYLIEHDPDSPLVEMLTAKIDKYENESPEFAEFNARVASIPSGV
ALLRTLMDQYHLTQSDFENEIGKKSLVSRILNGQRTLTLDHMRALAKRFGVPVSAFVGN

Download         Length: 420 bp

>AT187144 NZ_CP089778:c2416568-2416353 [Mycobacterium tuberculosis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References