Detailed information of TA system TA187114

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3756869..3757091
• Replicon: chromosome
• Accession: NZ_CP068283
• Organism: Escherichia coli strain CY598

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: JI738_RS18460
• Protein ID: WP_000141634.1
• Coordinates: 3756869..3756976 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3757025..3757091 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JI738_RS18435	3752122..3752850	-	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-
JI738_RS18440	3752886..3753074	-	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
JI738_RS18445	3753347..3754918	+	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
JI738_RS18450	3754915..3755106	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
JI738_RS18455	3755103..3756782	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
JI738_RS18460	3756869..3756976	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3757025..3757091	+	67	-	-	Antitoxin
JI738_RS18465	3757452..3758723	+	1272	WP_001295225.1	aromatic amino acid transport family protein	-
JI738_RS18470	3758753..3759757	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
JI738_RS18475	3759754..3760737	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
JI738_RS18480	3760748..3761650	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T187114 WP_000141634.1 NZ_CP068283:c3756976-3756869 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T187114 NZ_CP089778:704615-705016 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Nucleotide

• Length: 67 bp

>AT187114 NZ_CP068283:3757025-3757091 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin