Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3225938..3226631 Replicon chromosome
Accession NZ_CP068283
Organism Escherichia coli strain CY598

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JI738_RS15870 Protein ID WP_000415584.1
Coordinates 3226335..3226631 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JI738_RS15865 Protein ID WP_000650107.1
Coordinates 3225938..3226333 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JI738_RS15855 (3221802) 3221802..3224060 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
JI738_RS15860 (3224198) 3224198..3225805 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JI738_RS15865 (3225938) 3225938..3226333 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JI738_RS15870 (3226335) 3226335..3226631 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JI738_RS15875 (3226836) 3226836..3227318 - 483 WP_000183505.1 GyrI-like domain-containing protein -
JI738_RS15880 (3227371) 3227371..3227763 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JI738_RS15885 (3227915) 3227915..3228574 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
JI738_RS15890 (3228571) 3228571..3229920 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JI738_RS15895 (3229966) 3229966..3230298 - 333 WP_000917684.1 DUF2645 family protein -
JI738_RS15900 (3230617) 3230617..3231198 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JI738_RS15905 (3231229) 3231229..3231543 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T187111 WP_000415584.1 NZ_CP068283:c3226631-3226335 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T187111 NZ_CP089778:679051-679458 [Mycobacterium tuberculosis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT187111 WP_000650107.1 NZ_CP068283:c3226333-3225938 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT187111 NZ_CP089778:678839-679054 [Mycobacterium tuberculosis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References