Detailed information of TA system TA187090

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1447173..1447544
• Replicon: chromosome
• Accession: NZ_CP068283
• Organism: Escherichia coli strain CY598

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: F4VC37
• Locus tag: JI738_RS07215
• Protein ID: WP_001317028.1
• Coordinates: 1447350..1447544 (-)
• Length: 65 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1447173..1447351 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JI738_RS07190 (1443128)	1443128..1444501	+	1374	WP_000123737.1	ATP-dependent RNA helicase DbpA	-
JI738_RS07195 (1444630)	1444630..1445565	-	936	WP_001157406.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
JI738_RS07200 (1445617)	1445617..1446852	-	1236	WP_000040852.1	site-specific integrase	-
JI738_RS07205 (1446854)	1446854..1447069	-	216	WP_000079604.1	excisionase XisR	-
- (1447173)	1447173..1447351	+	179	NuclAT_0	-	Antitoxin
- (1447173)	1447173..1447351	+	179	NuclAT_0	-	Antitoxin
- (1447173)	1447173..1447351	+	179	NuclAT_0	-	Antitoxin
- (1447173)	1447173..1447351	+	179	NuclAT_0	-	Antitoxin
JI738_RS07210 (1447148)	1447148..1447357	-	210	WP_000276809.1	double-strand break reduction protein RcbA	-
JI738_RS07215 (1447350)	1447350..1447544	-	195	WP_001317028.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
JI738_RS07220 (1447601)	1447601..1448410	-	810	WP_000166319.1	recombination protein RecT	-
JI738_RS07225 (1448403)	1448403..1451003	-	2601	WP_000105143.1	exodeoxyribonuclease VIII	-
JI738_RS07230 (1451105)	1451105..1451380	-	276	WP_000632297.1	protein RacC	-
JI738_RS07235 (1451455)	1451455..1451625	-	171	WP_001352098.1	YdaE family protein	-
JI738_RS07240 (1451625)	1451625..1451846	-	222	WP_000560225.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1414438..1467291	52853

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-54)

Sequences

Toxin

Protein

• Length: 65 a.a.
• Molecular weight: 7018.89 Da
• Isoelectric Point: 8.9538

>T187090 WP_001317028.1 NZ_CP068283:c1447544-1447350 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALERWNKRTTGNNNGGVHV

Nucleotide

• Length: 195 bp

>T187090 NZ_CP089777:c2887342-2886947 [Mycobacterium tuberculosis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT187090 NZ_CP068283:1447173-1447351 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A7L6LHV7

Antitoxin