Detailed information of TA system TA187033

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 276320..276542
• Replicon: chromosome
• Accession: NZ_CP068281
• Organism: Escherichia coli strain CY706

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: JJW04_RS01350
• Protein ID: WP_000141634.1
• Coordinates: 276320..276427 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	276476..276542 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJW04_RS01325	271573..272301	-	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-
JJW04_RS01330	272337..272525	-	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
JJW04_RS01335	272798..274369	+	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
JJW04_RS01340	274366..274557	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
JJW04_RS01345	274554..276233	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
JJW04_RS01350	276320..276427	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	276476..276542	+	67	-	-	Antitoxin
JJW04_RS01355	276903..278174	+	1272	WP_001295225.1	aromatic amino acid transport family protein	-
JJW04_RS01360	278204..279208	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
JJW04_RS01365	279205..280188	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
JJW04_RS01370	280199..281101	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T187033 WP_000141634.1 NZ_CP068281:c276427-276320 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T187033 NZ_CP089776:2922378-2922818 [Mycobacterium tuberculosis]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT187033 NZ_CP068281:276476-276542 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin