Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4317094..4317787 Replicon chromosome
Accession NZ_CP068279
Organism Escherichia coli strain CY708

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JJW05_RS20965 Protein ID WP_000415584.1
Coordinates 4317491..4317787 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JJW05_RS20960 Protein ID WP_000650107.1
Coordinates 4317094..4317489 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJW05_RS20950 (4312958) 4312958..4315216 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
JJW05_RS20955 (4315354) 4315354..4316961 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JJW05_RS20960 (4317094) 4317094..4317489 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JJW05_RS20965 (4317491) 4317491..4317787 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JJW05_RS20970 (4317992) 4317992..4318474 - 483 WP_000183505.1 GyrI-like domain-containing protein -
JJW05_RS20975 (4318527) 4318527..4318919 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JJW05_RS20980 (4319071) 4319071..4319730 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
JJW05_RS20985 (4319727) 4319727..4321076 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JJW05_RS20990 (4321122) 4321122..4321454 - 333 WP_000917684.1 DUF2645 family protein -
JJW05_RS20995 (4321773) 4321773..4322354 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
JJW05_RS21000 (4322385) 4322385..4322699 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T187026 WP_000415584.1 NZ_CP068279:c4317787-4317491 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T187026 NZ_CP089776:c2360618-2360184 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT187026 WP_000650107.1 NZ_CP068279:c4317489-4317094 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT187026 NZ_CP089776:c2360879-2360625 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References