Detailed information of TA system TA186997

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 1092190..1092602
• Replicon: chromosome
• Accession: NZ_CP068279
• Organism: Escherichia coli strain CY708

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: JJW05_RS05190
• Protein ID: WP_000132601.1
• Coordinates: 1092190..1092531 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	1092526..1092602 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJW05_RS05180 (1089603)	1089603..1090649	-	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
JJW05_RS05185 (1090649)	1090649..1092028	-	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
JJW05_RS05190 (1092190)	1092190..1092531	-	342	WP_000132601.1	endoribonuclease SymE	Toxin
- (1092526)	1092526..1092602	+	77	NuclAT_13	-	Antitoxin
- (1092526)	1092526..1092602	+	77	NuclAT_13	-	Antitoxin
- (1092526)	1092526..1092602	+	77	NuclAT_13	-	Antitoxin
- (1092526)	1092526..1092602	+	77	NuclAT_13	-	Antitoxin
- (1092526)	1092526..1092602	+	77	NuclAT_14	-	Antitoxin
- (1092526)	1092526..1092602	+	77	NuclAT_14	-	Antitoxin
- (1092526)	1092526..1092602	+	77	NuclAT_14	-	Antitoxin
- (1092526)	1092526..1092602	+	77	NuclAT_14	-	Antitoxin
JJW05_RS05195 (1092759)	1092759..1094153	-	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
JJW05_RS05200 (1094150)	1094150..1095739	-	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1085105..1094153	9048

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T186997 WP_000132601.1 NZ_CP068279:c1092531-1092190 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T186997 NZ_CP089776:709428-709829 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin

Nucleotide

• Length: 77 bp

>AT186997 NZ_CP068279:1092526-1092602 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin