Detailed information of TA system TA186975

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2945542..2945813
• Replicon: chromosome
• Accession: NZ_CP068249
• Organism: Enterococcus faecalis strain T90-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A3N3Z2N6
• Locus tag: JG557_RS14480
• Protein ID: WP_073340360.1
• Coordinates: 2945542..2945682 (+)
• Length: 47 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2945615..2945813 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG557_RS14460	2940810..2941802	+	993	WP_002385136.1	biotin--[acetyl-CoA-carboxylase] ligase	-
JG557_RS14465	2942066..2942704	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
JG557_RS14470	2943392..2945008	+	1617	WP_002372620.1	phosphatase PAP2/LCP family protein	-
JG557_RS14475	2945226..2945423	+	198	WP_002358966.1	putative holin-like toxin	-
JG557_RS14480	2945542..2945682	+	141	WP_073340360.1	putative holin-like toxin	Toxin
-	2945615..2945813	-	199	-	-	Antitoxin
JG557_RS14485	2945976..2946119	+	144	WP_002388634.1	putative holin-like toxin	-
JG557_RS14490	2946314..2950189	-	3876	Protein_2831	WxL domain-containing protein	-
JG557_RS14495	2950170..2950538	-	369	WP_002388636.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-46)

Sequences

Toxin

Protein

• Length: 47 a.a.
• Molecular weight: 5218.33 Da
• Isoelectric Point: 10.3265

>T186975 WP_073340360.1 NZ_CP068249:2945542-2945682 [Enterococcus faecalis]
ISLKNTNKNIVYCTTYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 141 bp

>T186975 NZ_CP089775:c2976063-2975740 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin

Nucleotide

• Length: 199 bp

>AT186975 NZ_CP068249:c2945813-2945615 [Enterococcus faecalis]
TTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGA
CGGTGACCAATTGTATTATTTAAAAATAACCGTACTGGTCAAAGTAAACGGTTATTTTTTCTTGTCATTTTTAAGCAATT
TCACAATCAGCGCAATCAAAGCAATGGTAAACATACCAA

Structures

Toxin

• AlphaFold DB: A0A3N3Z2N6

Antitoxin