Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1912641..1913164 Replicon chromosome
Accession NZ_CP068247
Organism Staphylococcus sp. T93

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag JG553_RS09515 Protein ID WP_000074048.1
Coordinates 1912641..1912907 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag JG553_RS09520 Protein ID WP_000587616.1
Coordinates 1912907..1913164 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG553_RS09495 1907948..1909135 - 1188 WP_000026194.1 MFS transporter -
JG553_RS09500 1909531..1910307 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
JG553_RS09505 1910300..1910962 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
JG553_RS09510 1911210..1912286 - 1077 WP_001076671.1 M42 family metallopeptidase -
JG553_RS09515 1912641..1912907 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
JG553_RS09520 1912907..1913164 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JG553_RS09525 1913523..1913978 + 456 WP_000732082.1 DUF1307 domain-containing protein -
JG553_RS09530 1914146..1915723 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
JG553_RS09535 1915918..1916667 + 750 WP_000072443.1 hypothetical protein -
JG553_RS09540 1916891..1918084 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T186961 WP_000074048.1 NZ_CP068247:c1912907-1912641 [Staphylococcus sp. T93]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T186961 NZ_CP089775:c2205893-2205597 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT186961 WP_000587616.1 NZ_CP068247:c1913164-1912907 [Staphylococcus sp. T93]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT186961 NZ_CP089775:c2206141-2205890 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References