Detailed information of TA system TA186959

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1881140..1881324
• Replicon: chromosome
• Accession: NZ_CP068247
• Organism: Staphylococcus sp. T93

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: JG553_RS09375
• Protein ID: WP_000482650.1
• Coordinates: 1881217..1881324 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1881140..1881200 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG553_RS09360	1876670..1876837	-	168	WP_001790576.1	hypothetical protein	-
JG553_RS09365	1877068..1878801	-	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
JG553_RS09370	1878826..1880589	-	1764	WP_001064838.1	ABC transporter ATP-binding protein/permease	-
-	1881140..1881200	+	61	-	-	Antitoxin
JG553_RS09375	1881217..1881324	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
JG553_RS09380	1881458..1881844	-	387	WP_000779358.1	flippase GtxA	-
JG553_RS09385	1882112..1883254	+	1143	WP_001176863.1	glycerate kinase	-
JG553_RS09390	1883314..1883973	+	660	WP_000831298.1	membrane protein	-
JG553_RS09395	1884155..1885366	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
JG553_RS09400	1885489..1885962	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-103)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T186959 WP_000482650.1 NZ_CP068247:c1881324-1881217 [Staphylococcus sp. T93]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T186959 NZ_CP089775:c2196889-2196560 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT186959 NZ_CP068247:1881140-1881200 [Staphylococcus sp. T93]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin