Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1855788..1856305 Replicon chromosome
Accession NZ_CP068247
Organism Staphylococcus sp. T93

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag JG553_RS09240 Protein ID WP_000113262.1
Coordinates 1855788..1856054 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag JG553_RS09245 Protein ID WP_000584499.1
Coordinates 1856054..1856305 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JG553_RS09210 1851214..1851750 - 537 WP_000169315.1 GNAT family N-acetyltransferase -
JG553_RS09215 1851983..1852807 - 825 WP_000572040.1 formate/nitrite transporter family protein -
JG553_RS09220 1853024..1853206 - 183 WP_000230294.1 hypothetical protein -
JG553_RS09225 1853290..1853757 - 468 WP_000153344.1 SRPBCC domain-containing protein -
JG553_RS09230 1853943..1855493 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
JG553_RS09235 1855682..1855753 - 72 Protein_1781 hypothetical protein -
JG553_RS09240 1855788..1856054 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
JG553_RS09245 1856054..1856305 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JG553_RS09250 1856470..1856571 - 102 WP_001791744.1 hypothetical protein -
JG553_RS09255 1856578..1857177 - 600 WP_000162813.1 DsbA family protein -
JG553_RS09260 1857196..1857558 - 363 WP_000819843.1 DUF4467 domain-containing protein -
JG553_RS09265 1857813..1859063 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
JG553_RS09270 1859160..1859891 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
JG553_RS09275 1859888..1860607 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T186958 WP_000113262.1 NZ_CP068247:c1856054-1855788 [Staphylococcus sp. T93]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T186958 NZ_CP089775:1963020-1963268 [Mycobacterium tuberculosis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATAAGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT186958 WP_000584499.1 NZ_CP068247:c1856305-1856054 [Staphylococcus sp. T93]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT186958 NZ_CP089775:1962808-1963020 [Mycobacterium tuberculosis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References