Detailed information of TA system TA186957

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1590662..1590925
• Replicon: chromosome
• Accession: NZ_CP068247
• Organism: Staphylococcus sp. T93

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: JG553_RS07855
• Protein ID: WP_001802298.1
• Coordinates: 1590821..1590925 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	1590662..1590826 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG553_RS07835	1586902..1587567	-	666	WP_001024094.1	SDR family oxidoreductase	-
JG553_RS07840	1587719..1588039	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
JG553_RS07845	1588041..1589021	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
JG553_RS07850	1589287..1590378	+	1092	WP_000495671.1	lytic regulatory protein	-
JG553_RS07855	1590821..1590925	-	105	WP_001802298.1	hypothetical protein	Toxin
JG553_RS07860	1591086..1591569	-	484	Protein_1514	recombinase family protein	-
JG553_RS07865	1591612..1592748	-	1137	WP_000115562.1	SAP domain-containing protein	-
JG553_RS07870	1593037..1593129	+	93	WP_001790138.1	hypothetical protein	-
JG553_RS07875	1593834..1594691	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
JG553_RS07880	1594759..1595541	-	783	WP_000908177.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-116)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T186957 WP_001802298.1 NZ_CP068247:c1590925-1590821 [Staphylococcus sp. T93]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T186957 NZ_CP089775:c1942522-1942133 [Mycobacterium tuberculosis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT186957 NZ_CP068247:1590662-1590826 [Staphylococcus sp. T93]
GTAGCAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin