Detailed information of TA system TA186952

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1297836..1298018
• Replicon: chromosome
• Accession: NZ_CP068247
• Organism: Staphylococcus sp. T93

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: JG553_RS06230
• Protein ID: WP_001801861.1
• Coordinates: 1297836..1297931 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1297959..1298018 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JG553_RS06190	1293496..1294122	+	627	WP_000669046.1	hypothetical protein	-
JG553_RS06195	1294163..1294507	+	345	WP_000627551.1	DUF3969 family protein	-
JG553_RS06200	1294605..1295156	+	552	WP_000414205.1	hypothetical protein	-
JG553_RS06205	1295374..1296015	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
JG553_RS06210	1296129..1296314	-	186	WP_000809857.1	hypothetical protein	-
JG553_RS06215	1296316..1296492	-	177	WP_000375476.1	hypothetical protein	-
JG553_RS06220	1296503..1296886	-	384	WP_000070812.1	hypothetical protein	-
JG553_RS06225	1297490..1297633	-	144	WP_001549059.1	transposase	-
JG553_RS06230	1297836..1297931	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1297959..1298018	-	60	-	-	Antitoxin
JG553_RS06235	1298054..1298155	+	102	WP_001791893.1	hypothetical protein	-
JG553_RS06240	1298133..1298309	-	177	Protein_1234	transposase	-
JG553_RS06245	1298503..1298880	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1260395..1378902	118507

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T186952 WP_001801861.1 NZ_CP068247:1297836-1297931 [Staphylococcus sp. T93]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T186952 NZ_CP089775:c1395773-1395480 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Nucleotide

• Length: 60 bp

>AT186952 NZ_CP068247:c1298018-1297959 [Staphylococcus sp. T93]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin