Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5345168..5345763 Replicon chromosome
Accession NZ_CP068238
Organism Pseudomonas aeruginosa strain A39-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JHW37_RS25045 Protein ID WP_079741182.1
Coordinates 5345485..5345763 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JHW37_RS25040 Protein ID WP_034079919.1
Coordinates 5345168..5345473 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JHW37_RS25015 5340194..5341294 + 1101 WP_003151685.1 redox-regulated ATPase YchF -
JHW37_RS25020 5341366..5342415 - 1050 WP_079741181.1 lipase secretion chaperone -
JHW37_RS25025 5342496..5343425 - 930 WP_012077421.1 triacylglycerol lipase -
JHW37_RS25030 5343695..5344804 + 1110 WP_176540991.1 AraC family transcriptional regulator -
JHW37_RS25040 5345168..5345473 - 306 WP_034079919.1 HigA family addiction module antidote protein Antitoxin
JHW37_RS25045 5345485..5345763 - 279 WP_079741182.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JHW37_RS25050 5345816..5346469 - 654 Protein_4947 tyrosine-type recombinase/integrase -
JHW37_RS25055 5346563..5346811 - 249 WP_053817794.1 major capsid protein -
JHW37_RS25060 5346824..5347075 - 252 WP_038819938.1 hypothetical protein -
JHW37_RS25065 5347190..5347630 - 441 WP_053817795.1 hypothetical protein -
JHW37_RS25070 5348146..5348441 - 296 Protein_4951 DUF5447 family protein -
JHW37_RS25075 5348468..5348740 - 273 WP_004352675.1 hypothetical protein -
JHW37_RS25080 5348851..5349117 + 267 WP_053817796.1 hypothetical protein -
JHW37_RS25085 5349291..5350085 + 795 WP_079741184.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5343542..5356108 12566


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10632.17 Da        Isoelectric Point: 7.8937

>T186939 WP_079741182.1 NZ_CP068238:c5345763-5345485 [Pseudomonas aeruginosa]
MILTFRCDETRQVFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T186939 NZ_CP089775:715935-716336 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11170.58 Da        Isoelectric Point: 4.4462

>AT186939 WP_034079919.1 NZ_CP068238:c5345473-5345168 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLTELDISPAALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT186939 NZ_CP089775:715711-715938 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References