Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3987806..3988403 Replicon chromosome
Accession NZ_CP068237
Organism Klebsiella quasipneumoniae strain YDKL-002

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JJQ56_RS19310 Protein ID WP_153680567.1
Coordinates 3988086..3988403 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JJQ56_RS19305 Protein ID WP_049013658.1
Coordinates 3987806..3988093 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJQ56_RS19275 3983663..3983911 + 249 WP_202023851.1 DUF1158 domain-containing protein -
JJQ56_RS19280 3983929..3984270 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
JJQ56_RS19285 3984301..3985416 - 1116 WP_172977013.1 MBL fold metallo-hydrolase -
JJQ56_RS19290 3985596..3986180 + 585 WP_202023852.1 TetR/AcrR family transcriptional regulator -
JJQ56_RS19295 3986177..3986545 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
JJQ56_RS19300 3986665..3987318 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
JJQ56_RS19305 3987806..3988093 - 288 WP_049013658.1 helix-turn-helix transcriptional regulator Antitoxin
JJQ56_RS19310 3988086..3988403 - 318 WP_153680567.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJQ56_RS19315 3988588..3989631 - 1044 WP_202023853.1 DUF2157 domain-containing protein -
JJQ56_RS19320 3990343..3991209 - 867 WP_153680565.1 helix-turn-helix transcriptional regulator -
JJQ56_RS19325 3991318..3992745 + 1428 WP_202023854.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12138.40 Da        Isoelectric Point: 11.4088

>T186931 WP_153680567.1 NZ_CP068237:c3988403-3988086 [Klebsiella quasipneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGRTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T186931 NZ_CP089775:367091-367393 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10810.49 Da        Isoelectric Point: 10.2213

>AT186931 WP_049013658.1 NZ_CP068237:c3988093-3987806 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT186931 NZ_CP089775:367441-367662 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References