Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1244748..1245397 Replicon chromosome
Accession NZ_CP068234
Organism Leclercia adecarboxylata strain YZ30

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JJN11_RS05990 Protein ID WP_156654025.1
Coordinates 1245035..1245397 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JJN11_RS05985 Protein ID WP_103178550.1
Coordinates 1244748..1245047 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJN11_RS05975 (JJN11_05960) 1241238..1243211 + 1974 WP_156654024.1 PhoX family phosphatase -
JJN11_RS05980 (JJN11_05965) 1243315..1244703 + 1389 WP_103178549.1 phenylalanine transporter -
JJN11_RS05985 (JJN11_05970) 1244748..1245047 - 300 WP_103178550.1 helix-turn-helix transcriptional regulator Antitoxin
JJN11_RS05990 (JJN11_05975) 1245035..1245397 - 363 WP_156654025.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJN11_RS05995 (JJN11_05980) 1245651..1246889 + 1239 WP_103181038.1 MFS transporter -
JJN11_RS06000 (JJN11_05985) 1246904..1247929 + 1026 WP_156654026.1 sugar phosphate isomerase/epimerase -
JJN11_RS06005 (JJN11_05990) 1247922..1249064 + 1143 WP_103178553.1 Gfo/Idh/MocA family oxidoreductase -
JJN11_RS06010 (JJN11_05995) 1249140..1250114 + 975 WP_103178554.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13994.92 Da        Isoelectric Point: 7.3567

>T186907 WP_156654025.1 NZ_CP068234:c1245397-1245035 [Leclercia adecarboxylata]
MWEVETTDMFDEWFHHQKQDLKEDVLAALHILSEYGPQLGRPWVDTVKASQYTNMKELRIQHAGDPIRAFFAFDPGRQAI
TLCAGNKTVAGDKRFYKRMINIADAEFSKYLASKEAKWQR

Download         Length: 363 bp

>T186907 NZ_CP089774:2324820-2325230 [Mycobacterium tuberculosis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10971.70 Da        Isoelectric Point: 5.1667

>AT186907 WP_103178550.1 NZ_CP068234:c1245047-1244748 [Leclercia adecarboxylata]
MATLKELMAQQSEESQERIAAKVEELRIIVALNQLREELNMSQTELAAAMGVKQPTVAKIEQPDNDPRLSTLKRYVTALG
GEVSIDVILPTGKRVAFHI

Download         Length: 300 bp

>AT186907 NZ_CP089774:2324594-2324827 [Mycobacterium tuberculosis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References