Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4276817..4277445 Replicon chromosome
Accession NZ_CP068214
Organism Serratia ureilytica strain FDAARGOS_1089

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GSN3
Locus tag I6I46_RS20535 Protein ID WP_042785415.1
Coordinates 4276817..4277107 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B4GQY7
Locus tag I6I46_RS20540 Protein ID WP_015379150.1
Coordinates 4277122..4277445 (+) Length 108 a.a.

Genomic Context

I6I46_RS20525I6I46_RS20535I6I46_RS20540I6I46_RS20545I6I46_RS20550I6I46_RS20555I6I46_RS20560I6I46_RS20565I6I46_RS20530
Location: 4273231..4275252 (2022 bp)
Type: Others
Protein ID: WP_169539815.1
Location: 4276817..4277107 (291 bp)
Type: Toxin
Protein ID: WP_042785415.1
Location: 4277122..4277445 (324 bp)
Type: Antitoxin
Protein ID: WP_015379150.1
Location: 4277438..4277950 (513 bp)
Type: Others
Protein ID: WP_042785417.1
Location: 4278001..4278981 (981 bp)
Type: Others
Protein ID: WP_163966430.1
Location: 4278983..4279714 (732 bp)
Type: Others
Protein ID: WP_033644531.1
Location: 4279970..4280941 (972 bp)
Type: Others
Protein ID: WP_169539830.1
Location: 4281199..4282434 (1236 bp)
Type: Others
Protein ID: WP_028128305.1
Location: 4275447..4276586 (1140 bp)
Type: Others
Protein ID: WP_197752216.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6I46_RS205254273231..4275252+2022WP_169539815.1NADPH-dependent 2,4-dienoyl-CoA reductase-
I6I46_RS205304275447..4276586-1140WP_197752216.123S rRNA (guanine(1835)-N(2))-methyltransferase RlmG-
I6I46_RS205354276817..4277107+291WP_042785415.1type II toxin-antitoxin system RelE/ParE family toxinToxin
I6I46_RS205404277122..4277445+324WP_015379150.1HigA family addiction module antidote proteinAntitoxin
I6I46_RS205454277438..4277950+513WP_042785417.1M48 family metallopeptidase-
I6I46_RS205504278001..4278981+981WP_163966430.1Gfo/Idh/MocA family oxidoreductase-
I6I46_RS205554278983..4279714+732WP_033644531.1glutamine amidotransferase-
I6I46_RS205604279970..4280941+972WP_169539830.1TerC family protein-
I6I46_RS205654281199..4282434+1236WP_028128305.1serine/threonine transporter SstT-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11672.37 Da        Isoelectric Point: 10.4297

>T186852 WP_042785415.1 NZ_CP068214:4276817-4277107 [Serratia ureilytica]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPKGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T186852 NZ_CP089773:c2857476-2857057 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12141.78 Da        Isoelectric Point: 6.2285

>AT186852 WP_015379150.1 NZ_CP068214:4277122-4277445 [Serratia ureilytica]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILGRNITHA

Download         Length: 324 bp

>AT186852 NZ_CP089773:c2857697-2857473 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A8B4GSN3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A8B4GQY7

References