Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4276817..4277445 Replicon chromosome
Accession NZ_CP068214
Organism Serratia ureilytica strain FDAARGOS_1089

Toxin (Protein)


Gene name higB Uniprot ID A0A8B4GSN3
Locus tag I6I46_RS20535 Protein ID WP_042785415.1
Coordinates 4276817..4277107 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A8B4GQY7
Locus tag I6I46_RS20540 Protein ID WP_015379150.1
Coordinates 4277122..4277445 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I46_RS20525 4273231..4275252 + 2022 WP_169539815.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
I6I46_RS20530 4275447..4276586 - 1140 WP_197752216.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
I6I46_RS20535 4276817..4277107 + 291 WP_042785415.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I46_RS20540 4277122..4277445 + 324 WP_015379150.1 HigA family addiction module antidote protein Antitoxin
I6I46_RS20545 4277438..4277950 + 513 WP_042785417.1 M48 family metallopeptidase -
I6I46_RS20550 4278001..4278981 + 981 WP_163966430.1 Gfo/Idh/MocA family oxidoreductase -
I6I46_RS20555 4278983..4279714 + 732 WP_033644531.1 glutamine amidotransferase -
I6I46_RS20560 4279970..4280941 + 972 WP_169539830.1 TerC family protein -
I6I46_RS20565 4281199..4282434 + 1236 WP_028128305.1 serine/threonine transporter SstT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-71)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11672.37 Da        Isoelectric Point: 10.4297

>T186852 WP_042785415.1 NZ_CP068214:4276817-4277107 [Serratia ureilytica]
MIKSFRDRYLEQFYLEGRRSRLIPGALERQLARKLDMLAAAQQERDLHHPKGNYYKRLSGPFQGWSSLRVNMHWRLMFQW
RHDAAEKIYLDPHQDT

Download         Length: 291 bp

>T186852 NZ_CP089773:c2857476-2857057 [Mycobacterium tuberculosis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12141.78 Da        Isoelectric Point: 6.2285

>AT186852 WP_015379150.1 NZ_CP068214:4277122-4277445 [Serratia ureilytica]
MLETTTREPTTVGEVLQEEYLTPLGIGQEELAKVLGVTRATVNRLCNGHRRMSVAEANLFADLFETTADFWLNLQAAHDR
WEARQADAQRVRLRPIKEILGRNITHA

Download         Length: 324 bp

>AT186852 NZ_CP089773:c2857697-2857473 [Mycobacterium tuberculosis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4GSN3

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GQY7

References