Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3837560..3838212 Replicon chromosome
Accession NZ_CP068214
Organism Serratia ureilytica strain FDAARGOS_1089

Toxin (Protein)


Gene name higB Uniprot ID A0A8E2QRT0
Locus tag I6I46_RS18395 Protein ID WP_033644839.1
Coordinates 3837560..3837904 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6I46_RS18400 Protein ID WP_025304078.1
Coordinates 3837910..3838212 (+) Length 101 a.a.

Genomic Context

I6I46_RS18390I6I46_RS18395I6I46_RS18400I6I46_RS18410I6I46_RS18420I6I46_RS18425I6I46_RS18385I6I46_RS18405I6I46_RS18415
Location: 3836382..3837401 (1020 bp)
Type: Others
Protein ID: WP_033644840.1
Location: 3837560..3837904 (345 bp)
Type: Toxin
Protein ID: WP_033644839.1
Location: 3837910..3838212 (303 bp)
Type: Antitoxin
Protein ID: WP_025304078.1
Location: 3839636..3840559 (924 bp)
Type: Others
Protein ID: WP_042785280.1
Location: 3841604..3842488 (885 bp)
Type: Others
Protein ID: WP_069100465.1
Location: 3842557..3843204 (648 bp)
Type: Others
Protein ID: WP_033644834.1
Location: 3833903..3836161 (2259 bp)
Type: Others
Protein ID: WP_142002888.1
Location: 3838240..3839502 (1263 bp)
Type: Others
Protein ID: WP_033644838.1
Location: 3840587..3841495 (909 bp)
Type: Others
Protein ID: WP_033644836.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6I46_RS183853833903..3836161-2259WP_142002888.1molybdopterin guanine dinucleotide-containing S/N-oxide reductase-
I6I46_RS183903836382..3837401+1020WP_033644840.1HTH-type transcriptional regulator GalR-
I6I46_RS183953837560..3837904+345WP_033644839.1type II toxin-antitoxin system RelE/ParE family toxinToxin
I6I46_RS184003837910..3838212+303WP_025304078.1helix-turn-helix transcriptional regulatorAntitoxin
I6I46_RS184053838240..3839502-1263WP_033644838.1diaminopimelate decarboxylase-
I6I46_RS184103839636..3840559+924WP_042785280.1LysR family transcriptional regulator-
I6I46_RS184153840587..3841495-909WP_033644836.1LysR family transcriptional regulator-
I6I46_RS184203841604..3842488+885WP_069100465.1MBL fold metallo-hydrolase-
I6I46_RS184253842557..3843204+648WP_033644834.1DsbA family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(29-89)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13339.39 Da        Isoelectric Point: 10.8296

>T186849 WP_033644839.1 NZ_CP068214:3837560-3837904 [Serratia ureilytica]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSEAARQLKELRVQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDKRFYQRMLPIAAMEFSHYLATRR

Download         Length: 345 bp

>T186849 NZ_CP089773:c2367516-2367082 [Mycobacterium tuberculosis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11081.01 Da        Isoelectric Point: 10.3986

>AT186849 WP_025304078.1 NZ_CP068214:3837910-3838212 [Serratia ureilytica]
MAKPLSQLIDKLDPAVVAAARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Download         Length: 303 bp

>AT186849 NZ_CP089773:c2367777-2367523 [Mycobacterium tuberculosis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References