Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2412891..2413467 Replicon chromosome
Accession NZ_CP068166
Organism Corynebacterium aurimucosum strain FDAARGOS_1109

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag I6I66_RS11270 Protein ID WP_201828489.1
Coordinates 2413186..2413467 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag I6I66_RS11265 Protein ID WP_201828488.1
Coordinates 2412891..2413199 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I66_RS11240 2408583..2409425 - 843 WP_201828483.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
I6I66_RS11245 2409459..2410607 - 1149 WP_201828484.1 resuscitation-promoting factor -
I6I66_RS11250 2410853..2411677 - 825 WP_201828485.1 TatD family hydrolase -
I6I66_RS11255 2411702..2412196 + 495 WP_201828486.1 GNAT family N-acetyltransferase -
I6I66_RS11260 2412205..2412708 + 504 WP_201828487.1 GNAT family N-acetyltransferase -
I6I66_RS11265 2412891..2413199 - 309 WP_201828488.1 HigA family addiction module antidote protein Antitoxin
I6I66_RS11270 2413186..2413467 - 282 WP_201828489.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I66_RS11275 2413568..2414761 - 1194 WP_201828490.1 MFS transporter -
I6I66_RS11280 2414766..2416598 - 1833 WP_201828491.1 methionine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11133.64 Da        Isoelectric Point: 9.7215

>T186808 WP_201828489.1 NZ_CP068166:c2413467-2413186 [Corynebacterium aurimucosum]
MIQSFADRDTERLWNRERVPSIDSRIHSVALRKLRQLGYAQRLDDLRIPPGNRLEALKGDRRGQYSIRINDQWRICFRWT
ALGPEEVEIVDYH

Download         Length: 282 bp

>T186808 NZ_CP089772:3764035-3764292 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11288.09 Da        Isoelectric Point: 6.0655

>AT186808 WP_201828488.1 NZ_CP068166:c2413199-2412891 [Corynebacterium aurimucosum]
MTTTNKLPPVHPGEILMEDFLKDMGITQHKLAVSIGVPPRRINEIVHGKRAITADTALRLAKYFGISPQFWLGLQTHYDL
DVAEDKILAELDDIVPLQAASA

Download         Length: 309 bp

>AT186808 NZ_CP089772:3763763-3764038 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References