186805

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 146396..146985 Replicon chromosome
Accession NZ_CP068165
Organism Corynebacterium aurimucosum strain FDAARGOS_1110

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag I6I67_RS00770 Protein ID WP_010187287.1
Coordinates 146704..146985 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6I67_RS00765 Protein ID WP_010187286.1
Coordinates 146396..146695 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I67_RS00740 141991..142710 + 720 WP_010187276.1 hypothetical protein -
I6I67_RS00745 142710..143246 + 537 WP_010187279.1 DUF402 domain-containing protein -
I6I67_RS00750 143289..144209 + 921 WP_010187282.1 DUF808 domain-containing protein -
I6I67_RS00755 144213..145010 - 798 WP_010187284.1 zinc transporter ZupT -
I6I67_RS00760 145105..145947 + 843 WP_010187285.1 hypothetical protein -
I6I67_RS00765 146396..146695 - 300 WP_010187286.1 HigA family addiction module antidote protein Antitoxin
I6I67_RS00770 146704..146985 - 282 WP_010187287.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I67_RS00775 147176..148966 - 1791 WP_012714974.1 selenocysteine-specific translation elongation factor -
I6I67_RS00780 148967..150253 - 1287 WP_010187289.1 L-seryl-tRNA(Sec) selenium transferase -
I6I67_RS00790 150405..151382 + 978 WP_010187290.1 selenide, water dikinase SelD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(18-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10778.22 Da        Isoelectric Point: 10.7844

>T186805 WP_010187287.1 NZ_CP068165:c146985-146704 [Corynebacterium aurimucosum]
MIQSFGNRDTELVWLREASPRIDPRIHKTSNRKLHQLDAAVSLNSLRVPPGNRLEALKGDRKGTFSIRVNQQWRITFRWT
EAGPADVVIEDYH

Download         Length: 282 bp

>T186805 NZ_CP089772:3179063-3179326 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11067.62 Da        Isoelectric Point: 5.1215

>AT186805 WP_010187286.1 NZ_CP068165:c146695-146396 [Corynebacterium aurimucosum]
MSTKLYPPIHPGEVLNEDFIEAFGITQHKLAVEIGVPPRRINEIVHGKRGITADTALRLGRYFGIEPQYWLNLQSRYELE
VAEDAVADEINGIRPLGAA

Download         Length: 300 bp

>AT186805 NZ_CP089772:3178778-3179059 [Mycobacterium tuberculosis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References